ISRCTN79841657已完成未知
Reversal of over-anticoagulation using a ?tailored? vitamin K dosing regimen: towards a better management of anticoagulation therapy
ewcastle upon Tyne Hospitals NHS Foundation Trust0 个研究点目标入组 186 人开始时间: 2011年11月10日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 186
研究概览
简要总结
2017 results in https://www.ncbi.nlm.nih.gov/pubmed/28771671
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Patients on chronic therapy on warfarin presenting with an INR equal or greater than 6.0
- •2. Patient has provided written informed consent for participation in the study prior to any study specific procedures
- •3. 18 years of age or over
- •4. Male & female particpants
排除标准
- •1. Younger than 18 years
- •2. Life expectancy less than 10 days
- •3. Presence of major bleeding requiring immediate and complete correction of anticoagulation
- •4. A history of thromboembolic / major haemorrhagic event in the previous 3 months
- •5. nown bleeding disorder
- •6. Known sensitivity to vitamin K
- •7. Liver disease
- •8. Indication for acute normalisation of INR (such as imminent surgery)
- •9. Scheduled discontinuation of warfarin therapy
- •10. Receiving thrombolytic therapy within 48 hours
- •11. A platelet count less than 50x10 x 9 (superscript) cells/L
- •12. Unable to take oral medication
- •13. Unable to return to the clinic the next day for laboratory/clinical assessment
- •14. Participation in any other investigational study/trial within the past month
研究者
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