Conditioning of antihistaminergic effects
Completed
- Conditions
- Het onderzoek wordt bij gezonde proefpersonen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor verklaringsmodellen en therapeutische interventies voor allergene aandoeningen waarbij een verandering in de histaminerespons optreedt.Not applicable
- Registration Number
- NL-OMON42660
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 92
Inclusion Criteria
Between 18 and 35 years old; healthy, or when allergic, no current allergic rhinitis or allergic conjunctivitis symptoms
Exclusion Criteria
Somatic and/or psychiatric conditions (e.g. asthma), recent infection, recent use of medication (excluding oral contraceptives), recent vaccinations, current or recent (within past 3 months) allergic rhinitis or allergic conjunctivitis symptoms, any allergic condition other than allergic rhinitis or conjunctivitis, sensitivity to any substance used in this study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameter is self-reported mean itch during histamine<br /><br>iontophoresis. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters include the immediate inflammatory response (e.g.,<br /><br>cytokines), bronchodilation, wheal size, flare response, skin temperature, and<br /><br>self-reported skin condition, and scratching behaviour following histamine<br /><br>iontophoresis, skin conductance and heart rate, and self-reported wellbeing.<br /><br>The possible influence of genetic variants (e.g. the 5HTTLPR-genotype) and of<br /><br>psychological factors on conditioning will be explored.</p><br>