It is to compare the effects of ketofol and propofol as anaesthetic induction agent in patients undergoing supratentorial surgery.
Phase 2
- Conditions
- Health Condition 1: G939- Disorder of brain, unspecifiedHealth Condition 2: 4- Measurement and Monitoring
- Registration Number
- CTRI/2024/01/061850
- Lead Sponsor
- Pt B D Sharma University of Health Sciences PGIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Forty four patients of either sex in the age group 18-60 years belonging to ASA 1&2 scheduled to undergo elective supratentorial craniotomies with full GCS, size of lesion less than 5cm & midline shift less than 5mm under general anaesthesia will be enrolled in the study.
Exclusion Criteria
The patients with refusal for study, hypertension, obesity, psychiatric disorder, pregnancy, lactation, other methods of brain relaxation being used or planned such as EVD will be excluded from the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in mean arterial pressure in both groupsTimepoint: 1.At Baseline <br/ ><br>2. 2 mins after induction <br/ ><br>3. 3 mins after intubation <br/ ><br>4. 5 mins after intubation <br/ ><br>5. 10 mins after intubation <br/ ><br>6. 3 mins after skull pin insertion <br/ ><br>7. 5 mins after skull pin insertion <br/ ><br>8. at the time of skin incision <br/ ><br>9. At the time of bone flap removal <br/ ><br>10. At the time of dural opening <br/ ><br>11. At the time of skin suturing <br/ ><br>12. 5 mins after extubation
- Secondary Outcome Measures
Name Time Method 1. Changes in heart rate <br/ ><br>2. Brain relaxation score <br/ ><br>3. Pain on injection <br/ ><br>4. Myoclonic movements <br/ ><br>5. Any adverse events or complications <br/ ><br>in both the groupsTimepoint: 1.At Baseline <br/ ><br>2 mins after induction <br/ ><br>3 mins after intubation <br/ ><br>5 mins after intubation <br/ ><br>10 mins after intubation <br/ ><br>3 mins after skull pin insertion <br/ ><br>5 mins after skull pin insertion <br/ ><br>at the time of skin incision <br/ ><br>At the time of bone flap removal <br/ ><br>At the time of dural opening <br/ ><br>At the time of skin suturing <br/ ><br>5 mins after extubation <br/ ><br>2. After dural opening <br/ ><br>3.On administering the induction drug <br/ ><br>4. On administering the induction drug <br/ ><br>5. After extubation