Best ventilatory strategy for head and neck oncological surgeries

Not yet recruiting

• Conditions: Malignant neoplasm of floor of mouth, (2) ICD-10 Condition: C102||Malignant neoplasm of lateral wallof oropharynx,

• Registration Number: CTRI/2021/12/038825
• Lead Sponsor: Rajiv Gandhi Cancer Institute and research centre

Brief Summary

This will be a prospective study, observational, randomized study where patients undergoing prolonged surgeries of 6- 10 hrs duration will be enrolled into the study. After taking a written informed consent, 60 patients will be recruited into the study. Recruited patients will be randomly distributed on chit based system in three groups based on ventilatory modes- volume control, pressure control and volume controlled autoflow mode of ventilation. Ventilator settings will be done with a target tidal volume of 7ml/kg and frequency of ventilation will be adjusted to maintain an end tidal carbon dioxide between 35-45 mm of Hg. Intraoperatively recordings will be done for respiratory mechanics (end tidal carbon dioxide, tidal volume, minute ventilation, positive end-expiratory pressure, lung dynamic compliance, airway pressures) and ABG analysis (Fio2, PaO2/Fio2, ph, Paco2, Po2, lactate).

Respiratory parameters will be recorded every 15 minutes whereas ABG analysis will be done twice per case soon after induction and before reversal as per routine protocol in long surgeries. Rest of anesthetic and surgical management will be done as per usual standardized protocols.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-12-21
• Study Start: 2021-12-26

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

BMI between 25 to 29.9 6-10 hrs duration surgeries ASA 1-3.

Exclusion Criteria

• Patients with respiratory ailments like bronchitis, asthma etc.
• Cardiac patients with stent, CABG.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recording of dynamic compliance at different time points in all the ventilatory modes and comparing them.	15 minutes interval
More the dynamic compliance,better is the mode.	15 minutes interval

Secondary Outcome Measures

Name	Time	Method
Recording and comparing resistance, peak and plateau airway pressure.	15 minutes interval

Trial Locations

Locations (1)

Rajiv Gandhi Cancer Institute and research centre; 🇮🇳 West, DELHI, India

Rajiv Gandhi Cancer Institute and research centre

🇮🇳West, DELHI, India

Dr Nitesh Goel

Principal investigator

9717773292

drniteshgoel@gmail.com