Renal Recovery After PEEP Weaning in ARDS (RE2SDRA)

Completed

• Conditions: ARDS (Acute Respiratory Distress Syndrome); AKI - Acute Kidney Injury

• Registration Number: NCT06754787
• Lead Sponsor: University Hospital, Brest

Brief Summary

The purpose of the study is to investigate renal recovery in ARDS after PEEP weaning. The primary outcome was the variation of the hourly urine output (HUO), 48 h after PEEP weaning. Secondary outcomes were the need for RRT and mortality. Two groups were defined depending wether hourly urine output was greater or lower than 0.35 mL/kg/h.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-03-21
• Primary Completion: 2024-06-01
• Study Completion: 2024-08-01
• Status Verified: 2024-10
• Study First Submitted: 2024-12-11
• Study First Submitted QC: 2024-12-23
• Last Update Submitted: 2024-12-23
• Study First Posted: 2025-01-01
• Last Update Posted: 2025-01-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• intubated for more than 48 hours, exposed to a PEEP≥ 8 cmH20

Exclusion Criteria

• chronic end-stage renal disease on admission
• refusal to participate
• non-opposition could not be obtained from themselves or their trusted support person in the event of incapacity
• under legal protection.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Variation of the hourly urine output on day 2 after PEEP weaning	From enrollement to day 2 after PEEP weaning	Variation of the hourly urine output on day 2 after PEEP weaning

Trial Locations

Locations (1)

Chu Brest; 🇫🇷 Brest, France