Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography

Completed

• Conditions: Respiratory Failure; Fluid Responsiveness; Fluid Overload; Circulatory Failure

• Registration Number: NCT02992002
• Lead Sponsor: University Hospital Schleswig-Holstein

Brief Summary

The study investigates the influence of a clinically indicated fluid challenge on end-expiratory lung impedance, assessed by electrical impedance tomography (EIT). EIT data will be collected before, during and after infusion of 500 ml of crystalloid solution in mechanically ventilated patients on an operative intensive care unit.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12
• Study First Submitted: 2016-12-09
• Study First Submitted QC: 2016-12-09
• Study First Posted: 2016-12-14
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-02
• Last Update Posted: 2018-05-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• patients on mechanical ventilation
• clincial decision to monitor regional ventilation with electrical impedance tomography
• clinical indication for fluid challenge
• established cardiac output monitoring with transpulmonary thermodilution

Exclusion Criteria

• age < 18 years
• open lung injuries
• instable injury of spine or cranium
• thoracic metal implants
• body mass index > 35

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in end-expiratory lung impedance (EELI)	15-30 minutes	To assess the effect of fluid challenge on EELI, the change in EELI during the fluid challenge will be measured by electrical impedance tomography and will be compared to the change in EELI during the last 15 minutes before start of the fluid challenge.

Secondary Outcome Measures

Name	Time	Method
Correlation between change in end-expiratory lung impedance and change in intrathoracic blood volume	15-30 minutes	We will assess the correlation between the change in end-expiratory lung impedance during infusion of 500 ml of crystalloid solution and the change in intrathoracic blood volume (assessed by transpulmonary thermodilution) during the same time period.
Fluid responsiveness	15-30 minutes	We will investigate whether the ratio of cardiac-related impedance changes to ventilation-related impedance changes, measured by EIT at baseline (i.e. before start of fluid challenge), can predict fluid responsiveness, defined as an increase in stroke volume of greater or equal to 15% compared to baseline.

Trial Locations

Locations (1)

University Medical Center Schleswig Holstein, Campus Kiel; 🇩🇪 Kiel, Schleswig-Holstein, Germany