The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure
Not Applicable
- Conditions
- Heart Failure, Congestive
- Registration Number
- NCT00132106
- Lead Sponsor
- Radboud University Medical Center
- Brief Summary
The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is increased seem to inhibit/reduce forearm glucose uptake. Inversely a decrease in sympathetic activity seems to increase glucose uptake. This study analyzes the effect of alfa-adrenergic receptor blockade (counteracting sympathetic influence) on insulin-stimulated forearm glucose uptake in patients with increased sympathetic activity (patients with chronic heart failure).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Heart failure of at least New York Heart Association (NYHA) class II
- Left ventricular ejection fraction (LVEF) <= 40%
- Age 18-75 years
Exclusion Criteria
- Alfa-blockers, or beta-blockers with alfa-blocking activity (carvedilol)
- Tricyclic antidepressants
- Warfarin derivatives (acetylic salicylic acid and clopidogrel are allowed)
- Hospitalisation in 6 weeks prior to the study
- Any change in medication in 6 weeks prior to the study
- Unstable angina
- Orthopnoea
- Known chronic disease of the autonomic nervous system
- Diabetes mellitus
- Oedema of the lower extremities, complicating the insertion of a venous catheter in a vein on the foot
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method change in glucose uptake
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Radboud University Nijmegen Medical Centre
🇳🇱Nijmegen, Netherlands