Adrenergic blockade in adult burns patients

Phase 2

• Conditions: Burn injury greater than 30% body surface area; Injuries and Accidents - Burns

• Registration Number: ACTRN12611000550909
• Lead Sponsor: Burns, Trauma & Critical Care Research Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-05-31
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

Acute burns patients
18years of age and over
30% total burns surface area,
Ready for discharge from intensive care, at a stage when they do not require inotropic support, are non septic, antibiotic free and capable of spontaneous breathing on a high flow humidifier

Exclusion Criteria

Concomitant multi-trauma,
Pregnancy,
Lactation,
A premorbid history of asthma or bronchospasm,
Peripheral arterial disease,
Diabetes,
Systolic blood pressure<100mmHg or mean arterial pressure of < 65mmHg,
Heart rate<60bpm,
Heart block on ECG,
Previous use of beta blockers before the burn injury, or previous prescription for greater than 24 hours within the preceding 24 hours,
Allergic disorders
Any cardiovascular conditions (hypertension, coronary artery disease, left ventricular systolic impairment, pulmonary hypertension, right ventricular impairment, sick sinus syndrome, heart block),
Renal or hepatic impairment,
Hyperthyroidism,
Previous depressive illness
Compassionate care only

Study & Design

• Study Type: Interventional
• Study Design: Not specified