A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Not Applicable

Recruiting

• Conditions: Healthy; Spontaneous Coronary Artery Dissection
• Interventions: Other: Arterial Tonometry; Diagnostic Test: Echocardiogram; Diagnostic Test: Carotid Ultrasounds; Diagnostic Test: Elastography; Other: Ankle-Brachial Index; Other: Microneurography with sympathoexcitatory maneuvers

• Registration Number: NCT05699200
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-01-16
• Study First Submitted QC: 2023-01-16
• Study First Posted: 2023-01-26
• Study Start: 2023-06-01
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-06
• Last Update Posted: 2024-06-10
• Primary Completion: 2027-08
• Study Completion: 2027-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
• For controls: no cardiac disease history

Exclusion Criteria

• Pregnancy
• Known or suspected unstable cardiac condition within 4 weeks of the study
• Active treatment with anticoagulation or dual antiplatelet therapy
• Prisoner

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy Control Group	Microneurography with sympathoexcitatory maneuvers	Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Healthy Control Group	Carotid Ultrasounds	Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Spontaneous coronary artery dissection (SCAD) group	Echocardiogram	Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Healthy Control Group	Echocardiogram	Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Spontaneous coronary artery dissection (SCAD) group	Carotid Ultrasounds	Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Healthy Control Group	Arterial Tonometry	Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Spontaneous coronary artery dissection (SCAD) group	Elastography	Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Spontaneous coronary artery dissection (SCAD) group	Ankle-Brachial Index	Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Spontaneous coronary artery dissection (SCAD) group	Microneurography with sympathoexcitatory maneuvers	Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Healthy Control Group	Ankle-Brachial Index	Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Spontaneous coronary artery dissection (SCAD) group	Arterial Tonometry	Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Healthy Control Group	Elastography	Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.

Primary Outcome Measures

Name	Time	Method
Arterial stiffness	Baseline	Measured by carotid ultrasound pulse wave velocity reporting in m/s
Sympathetic response to stress	Baseline	Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min).
Arterial thickness	Baseline	Measured by carotid ultrasound intimal media thickness reporting in mm
Baroreflex sensitivity	Baseline	The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg)

Trial Locations

Locations (1)

Mayo Clinic Rochester; 🇺🇸 Rochester, Minnesota, United States