Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic Denervation

Completed

• Conditions: Arterial Hypertension; Resistant Arterial Hypertension

• Registration Number: NCT03243045
• Lead Sponsor: National Institute of Cardiology, Laranjeiras, Brazil

Brief Summary

It has been proposed that the modulation of the activity of the sympathetic nervous system, through renal sympathetic denervation, besides reducing blood pressure, would promote an improvement in vascular reactivity and consequent improvement of macro and microcirculation.

The present study aimed to investigate the influence of the renal sympathetic denervation on the skin microvascular function of patients presenting with resistant arterial hypertension.

Detailed Description

Arterial hypertension is still a serious public health problem with considerable social and economic impact. Arterial hypertension is the result from a complex interaction between environmental and genetic factors that initiate and perpetuate elevated blood pressure. Studies show that about 10% of patients undergoing treatment have resistant hypertension, defined as high blood pressure refractory to at least three antihypertensive drugs. It is known that the sympathetic nervous system plays a fundamental role in the pathophysiology of hypertension, contributing to metabolic and vascular changes. The sympathetic nervous system has also a major role in the pathophysiology of arterial hypertension. Arterial hypertension has also been associated with functional microcirculatory alterations as well as systemic microvascular endothelial dysfunction in hypertensive patients, confirmed by different microcirculatory flowmetry techniques. In this context, it has been proposed that the modulation of the sympathetic nervous system through renal sympathetic denervation, besides reducing blood pressure, would promote an improvement in vascular reactivity and consequent improvement of macro and microcirculation.

The present study aimed to investigate the influence of the renal sympathetic denervation on the skin microvascular function of patients with resistant hypertension.

Study Timeline

• Study Start: 2017-03-01
• Study First Submitted: 2017-08-03
• Study First Submitted QC: 2017-08-07
• Study First Posted: 2017-08-08
• Status Verified: 2020-01
• Primary Completion: 2020-01-06
• Study Completion: 2020-01-06
• Last Update Submitted: 2020-01-06
• Last Update Posted: 2020-01-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Resistant arterial hypertension under pharmacological treatment

Exclusion Criteria

• secondary arterial hypertension
• renal dysfunction
• severe kidney disease
• congestive heart failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cutaneous microvascular reactivity	Before and one, three, six and twelve months after intervention	Evaluation of microvascular reactivity using laser speckle contrast imaging
Cutaneous microvascular flow	Before and one, three, six and twelve months after intervention	Evaluation of the microvascular flow using laser speckle contrast imaging

Secondary Outcome Measures

Name	Time	Method
Cutaneous capillary density	Before and one, three, six and twelve months after intervention	Evaluation of cutaneous capillary density and reactivity using video-capillaroscopy

Trial Locations

Locations (1)

National Institute of Cardiology; 🇧🇷 Rio de Janeiro, Brazil