Measurement of the concentrations of lithium, sodium, potassium and creatinine in the saliva of patients with treatment-resistant depression.

Recruiting

• Conditions: Bipolar affective disorder; F32; F31; Depressive episode

• Registration Number: DRKS00031566
• Lead Sponsor: Medizinische Hochschule Brandenburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Diagnosis of Unipolar Depression or Bipolar Disorder (I and II).
-Existing or planned lithium therapy in inpatient and outpatient treatment
-Existing capacity to give consent
-Existence of written informed consent

Exclusion Criteria

-Diagnosis of antisocial or other severe personality disorder.
-Schizophrenia
-Severe cognitive impairment e.g. dementia or severe intelligence impairment
-Withdrawal of informed consent
-Existing renal insufficiency stage 3 and above (GFR 30-59), severe cardiac or circulatory disease
-Institutionalization by court or official order (according to AMG § 40 (1) 4).

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Investigation of the correlation between lithium, sodium and creatinine concentrations in venous blood, whole blood and saliva over the period of one year with at least four measurements.

Secondary Outcome Measures

Name	Time	Method
Determination of the potential of saliva as a more accessible and less invasive medium for the determination of lithium concentration