Comparison of Efficacy of Oral Fluconazole Versus Oral Itraconazole in the Treatment of Pityriasis Versicolor

Phase 4

Recruiting

• Conditions: Pityriasis Versicolor
• Interventions: Drug: Fluconazole; Drug: Itraconazole

• Registration Number: NCT06922344
• Lead Sponsor: Khyber Teaching Hospital

Brief Summary

This study compares the efficacy of two drugs, namely flucanazole and itraconazole for the treatment of a common fungal infection of skin.

Detailed Description

Pityriasis versicolor is a common fungal infection of the superficial skin layers. Avalible treatment options include topical and systemic drugs. fluconazole and itraconazole are commonly used systemic agents. The aim of this study is to compare the efficacy of the two systemic drugs.

Study Timeline

• Study Start: 2025-03-01
• Status Verified: 2025-04
• Study First Submitted: 2025-04-03
• Study First Submitted QC: 2025-04-09
• Last Update Submitted: 2025-04-09
• Study First Posted: 2025-04-10
• Last Update Posted: 2025-04-10
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

• All cases of Pityriasis versicolor

Exclusion Criteria

• Patients with history of chronic renal or liver disease, malignancy , or undergoing any kind of chemotherapy or radiotherapy or having cardiac conduction abnormalities.
• Patients who received any anti-fungal therapy in the last one month.
• Pregnant or lactating women.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A, Fluconazole group	Fluconazole	Group A consists of patients in whom oral fluconazole is given in dose of 300mg once weekly for 2 weeks.
Group B, Itraconazole group	Itraconazole	Group B consists of patients in whom oral Itraconazole is given in dose of 100mg Twice for 5 days.

Primary Outcome Measures

Name	Time	Method
Efficacy of Treatment	Upto 8 weeks	Efficacy of treatment is defined by absence of scaling by naked eye examination ,absence of yellow or golden scale reflection on woods lamp examination and absence of fungal hyphae on microscopic examination.

Trial Locations

Locations (1)

Khyber Teaching Hospital; 🇵🇰 Peshawar, KPK, Pakistan