NCT04464265已完成4 期
Magnetic Resonance Imaging of the Effect of Music Listening on Brain Activity Under Anesthesia
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 2
- 主要终点
- Blood Oxygen Level Dependent (BOLD) Response to Sensory Stimuli During Sedation
研究概览
简要总结
This study is to better understand the systems-level neuronal mechanisms by which general anesthetics produce loss of consciousness.The researchers believe that anesthetics suppress consciousness by disrupting the functioning of large-scale brain networks that support information integration in the brain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •American Society of Anesthesiologist physical status of 1 (ASA-1), Healthy, non-smoking, no or minimal alcohol use
- •Right-handed
- •Body mass index (BMI) of less than 30
- •English speakers
排除标准
- •Medical contraindication to Magnetic Resonance Imaging (MRI) scanning
- •Unable to undergo MRI scanning because of possible pregnancy
- •BMI over 30
- •Tattoos in the head or neck region
- •Unwilling to abstain from alcohol for 24 hours prior to dosing
结局指标
主要结局
Blood Oxygen Level Dependent (BOLD) Response to Sensory Stimuli During Sedation
时间窗: 60 minutes
Music evoked activity was quantified by measurements of the fMRI BOLD signal. Neural response to a natural auditory stimulus, music, was assessed during both conscious and anesthetized states. Measurements were taken at baseline (30 minutes) and during anesthesia (60 minutes).
次要结局
- Average Squeeze Pressure Over 60 Minutes(60 minutes)
研究者
Anthony G Hudetz
Professor of Anesthesiology
University of Michigan
研究点 (2)
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