Adult Onset Asthma: the first 5 years.
- Conditions
- Adult onset asthmaSevere asthmaPhenotypingMarkers
- Registration Number
- NL-OMON22527
- Lead Sponsor
- Amsterdam Medical Centre, department of pulmonology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
1. Age between 18-75 years;
2. Physicians diagnosis of asthma after age of 18;
Exclusion Criteria
1. Smoking history >10py and a fixed airflow obstruction (FEV1 <80%pb and FEV1/FVC<0.70pb) without reversibility in FEV1>12% and 200ml;
2. Pregnancy;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Studie 1: Characterizing patients with adult onset asthma with respect to clinical, functional and inflammatory parameters. Subtypes will be defined by cluster analysis; risk factors of disease and poor quality of life will be defined.<br><br /><br /><br>Studie 2: Clinical, functional and inflammatory parameters will be compared between 100 patients with recent onset asthma (1-5yr) and 100 patients with longstading adult onset asthma (>5yr).<br><br /><br /><br>Studie 3: Three well defined subtypes will be compared by measurements of small airway function and sputum cells.
- Secondary Outcome Measures
Name Time Method