Effects of timing of food intake on glucose metabolism and the brain during a hypocaloric diet in obese subjects
Recruiting
- Conditions
- obesity, type 2 diabetes
- Registration Number
- NL-OMON22981
- Lead Sponsor
- AMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
men
>50 y
Exclusion Criteria
Use of any medication except for those related to treatment of components of the metabolic syndrome (excluding insulin, oral glucose lowering drugs, beta-blockers)
Any actual medical condition except for treated hypothyroidism and the metabolic syndrome
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Insulin sensitivity (hyperinsulinemic euglycemic clamp)<br /><br>2. Diencephalic SERT ( [123I]FP-CIT SPECT) <br /><br>3. Brain 5-HT neurotransmission (pharmacological MRI (phMRI) using citalopram). <br>
- Secondary Outcome Measures
Name Time Method Motivation and impulse control<br /><br>Abdominal and liver fat<br /><br>Circulating hormones and substrates: blood drawing<br /><br>Sleep duration<br /><br>Resting energy expenditure<br /><br>Sympathetic and parasympathetic activity<br /><br>Feeding behaviour<br>