The effect of meal timing on postprandial glucose in healthy volunteers

Not Applicable

Recruiting

• Conditions: postprandial glucose; Type 2 Diabetes; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12616000164493
• Lead Sponsor: Dr Maxine Bonham

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Healthy adults (18-50 years) who do not currently engage in shift work and have regular sleeping patterns

Exclusion Criteria

Currently shift workers or night workers
Age: > 50 years
Body mass index: <18.5 and > 30
Diagnosed with type 2 diabetes or taking anti-diabetic medication (oral hypoglycaemic agents)
Impaired fasting glucose
Taking lipid-lowering medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glucose (incremental area under the curve) is assessed from blood samples (finger prick in part one and venous blood in study two)[ Two hour glucose iAUC will be calculated from finger prick blood samples at seven time points (-10, 0, 15, 30, 45, 60, 90 and 120 mins) after the OGTT (part one). Please note the -10 sample and 0 min sample will be averaged. <br>Three hour glucose iAUC will be calculated from venous blood samples at nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after the low GI meal (part two) ]

Secondary Outcome Measures

Name	Time	Method
<br>Insulin (incremental area under the curve) is assessed from blood samples (finger prick in part one and venous blood in study two)[Three hour insulin iAUC will be calculated from venous blood samples at nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after the low GI meal (part two) <br><br>Samples were not collected for insulin in part one (OGTT)]