Effects of timing of food intake on glucose metabolism and the brain during a hypocaloric diet in obese subjects
- Conditions
- type 2 diabetes10018424
- Registration Number
- NL-OMON40991
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 25
- Male
- BMI * 30kg/m2
- Age 50-80 years
- At least 3 out of 5 metabolic syndrome criteria: fasting plasma glucose * 5.6 mmol/l, triglycerides * 1.7 mmol/l, waist-circumference > 102 cm, HDL-cholesterol 1.04 mmol/l, blood pressure * 130/85 mmHg
- Stable weight three months prior to study inclusion
- Use of any medication except for those related to treatment of components of the metabolic syndrome (excluding insulin, oral glucose lowering drugs, beta-blockers)
- Any actual medical condition except for treated hypothyroidism and the metabolic syndrome
- History of any psychiatric disorder
- Shift work
- Irregular sleep pattern
- Intensive sports (>3/week)
- Restrained eaters
- History of eating disorders (anorexia, binge eating, bulimia)
- Smoking, XTC, amphetamine or cocaine abuse
- Alcohol abuse (>3/day)
- Contraindication MRI
- Lactose intolerance
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Insulin sensitivity: 2-step hyperinsulinemic euglycemic clamp with stable<br /><br>glucose isotope tracer<br /><br>* Serotonin transporter availability : [123I]FP-CIT SPECT scan<br /><br>* Serotonergic activity: pharmacological MRI using citalopram</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Motivation and impulse control: functional MRI<br /><br>* Abdominal and liver fat: magnetic resonance sprectroscopy (MRS)<br /><br>* Circulating hormones and substrates: blood drawing<br /><br>* Sleep duration: Actiwatch<br /><br>* Sympathetic and parasympathetic activity: heart rate variability<br /><br>* Feeding behaviour: questionnaires</p><br>