Influence of bicarbonate rich mineral water on acid-base metabolism and indicators on bone turnover

Not Applicable

• Conditions: E87; Other disorders of fluid, electrolyte and acid-base balance; Acid base equilibrium and bone metabolism

• Registration Number: DRKS00012290
• Lead Sponsor: Institut für Lebensmittelwissenschaft und Humanernährung

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-07
• Study Completion: 2017-10-10
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 129

Inclusion Criteria

Healthy, competent men and women aged 18-75 years
- omnivorous
- BMI 18,5-32 kg/m2
- Ability and willingness of study participamts to follow study leaders instruction
- written consent after information about study content, procedure and risks

Exclusion Criteria

- allergies regarding study products contents
- individuals that follow an alternative diet (e.g. vegetarian, vegan, paleo, food combining)
- Intake of medicine that has an influence on calcium- and bone metabolism (diuretics, corticosteroids, anticonvulsants, bisphosphonate)
- Intake of calcium or magnesium supplements
- diagnosed and treated osteoporosis
- Intake of isoflavonoids
- hormone replacement therapy 6 months before beginning of the study or during the intervention
- severe chronic diseases (diabetes mellitus, kidney disease, liver disease, manifested coronary diseases, cancer, thyroid disease)
- individuals with urinary stones or intake of urine acidifying medicine
- diagnosed blood coagulation disorder or intake of coagulation-inhibiting medicine
- chronic gastrointestinal diseases (colitis ulcerosa, morbus crohn, pancreas insufficiency)
- regular intake of laxative medicine
- pregnancy or lactation
-addiction to alcohol and/or drugs
- missing consent or refusal/reset of the consent
- participation in another clinical trial at the same time or within the past 30 days
- planned surgery within the next 3 months

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
et acid excretion (NEA) analitically determined by means of the titratable acid (TA) of the ammonium (NH4+) and bicarbonate (HCO3-) in the urine (NEA = TA + NH4+ – HCO3-) at the beginning and at the end of the intervention<br><br>

Secondary Outcome Measures

Name	Time	Method
- parameters of the bone turnover (osteocalcin, carboxy-terminal collagen crosslinks (CTX) in EDTA blood, amino-terminal propeptide of type I collagen (P1NP) at the beginning and and the end of the intervention<br>- potential renal acid load (PRAL) of different mineral waters and the consumed food using valid food questionnaires<br>