Fitness Assessment in Young Adults Recovered From Lymphoma
- Conditions
- Young AdultsLymphoma, Non-HodgkinHodgkin Disease
- Interventions
- Other: Indirect calorimetric test during submaximal exercise
- Registration Number
- NCT05188755
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle.
Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population.
Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) .
The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
- Young adult male or female, aged 18 to 25
- giving free and informed consent
- Hodgkin lymphoma or non-Hodgkin lymphoma in the healing stage
- Cured (defined by an undetectable disease at the end of treatment) for at least one year and maximum 6 years of lymphoma or Hodgkin's disease
- Legal incapable adults
- People under judicial protection
- Treatment with systemic glucocorticoids for more than a week, during the 30 days preceding the tests
- Medical contraindication to the practice of physical exercise
- Any pathologies (other than the history of lymphoma for the cases) likely to affect the metabolism or the muscle mass
- Any treatment that may have an influence on the energy metabolism
- Active infection
- Pregnant, breastfeeding, or likely to be
- Subject's refusal to participate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description young adults recovered from lymphoma or Hodgkin's disease Indirect calorimetric test during submaximal exercise young adults recovered from lymphoma or Hodgkin's disease Healthy controls Indirect calorimetric test during submaximal exercise sex and age matched healthy controls
- Primary Outcome Measures
Name Time Method fat oxidation rate day at 11:30 am during one day maximum rate of lipid oxidation (in mg/ml)
- Secondary Outcome Measures
Name Time Method blood N-terminal pro-B natriuretic peptide at 07:30 am in fasted condition during one day blood N-terminal pro-B natriuretic peptide level in g/L
blood insulinemia at 07:30 am in fasted condition during one day blood value of insulin in pmol/L
physical activity level from day 2 to day 5 daily energy expenditure (in Kcal)
rest metabolism at 08:00 am in fasted condition during one day energy expenditure at rest in kcal.
blood troponin at 07:30 am in fasted condition during one day blood troponin level in g/L
Body composition: fat at 07:30 am during one day percentage of fat
physical capacity at 08:45 am during one day chair test (time in second held in position)
sedentary level from day 2 to day 5 total sedentary time (in min) evaluated by accelerometer for 4 days
blood lipids at 07:30 am in fasted condition during one day blood lipids level in g/L
blood glucose at 07:30 am in fasted condition during one day blood glucose level in g/L
Body composition: lean mass at 07:30 am during one day percentage of lean mass
cardiac output at 11:30 am during one day Systolic Ejection Volume in mL evaluated at rest and during submaximal exercise
peripheral quantitative computed tomography at 10:45 am during one day Cross-sectional area of thigh muscles and intermuscular adipose tissue were assessed for muscle at 40% of the length between the greater trochanter and the mid-patella of the right leg
physical condition at 08:45 am during one day 3 min step-test (number of ascent / descent step)
Trial Locations
- Locations (1)
CHU de Clermont-Ferrand
🇫🇷Clermont-Ferrand, France