A new approach to determine the age of (sub)acute and chronic subdural hematomas

Completed

Conditions: bleeding in the subdural space
Subdural hematoma
10007963

Registration Number: NL-OMON50105

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 25

Inclusion Criteria

* 18 years or older;
* the patients, or their legal representative, have signed an informed consent;
* have a traumatic acute, subacute or chronic subdural hematoma;
* the date of trauma must be known or when the expected trauma occurred more
than 14 days ago and the patient is not sure of the date, an approximate
estimate of the date.

Exclusion Criteria

* recurrent subdural hematoma;
* previous surgery for subdural hematoma in the past 365 days;
* inability to obtain informed consent from the patient (or when the patient
has a depressed level of consciousness their legal representative), including
language barrier.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the concentrations over time of six biomarkers<br /><br>(UCHL1, ICAM5, NFH, MBP, GFAP and NGF) in subdural blood.<br /><br><br /><br>GFAP Glial fibrillary acidic protein<br /><br>ICAM-5 Intercellular adhesion molecule 5<br /><br>MBP Myelin basic protein<br /><br>NFH Neurofilament heavy chain<br /><br>NGF Nerve growth factor<br /><br>UHCL1 Ubiquitin C-terminal hydrolase L1</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The second study parameters are hemoglobin derivatives (HbO2, met-Hb, HC,<br /><br>Biliverdin and Bilirubin) in subdural blood.<br /><br><br /><br>Hb Hemoglobin<br /><br>HbO2 Oxyhemoglobin<br /><br>HC Hemichrome</p><br>