Comparison of palanosetron and dexamethasone with ondansetron and dexamethasone for prevention of nausea and vomiting after operation in cancer patients receiving opioid based pain relief medicine

Phase 3

Completed

• Conditions: Health Condition 1: null- Cancer patients posted for ovarian cancer surgery

• Registration Number: CTRI/2015/09/006223
• Lead Sponsor: il

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

18-70 years old female patients, American Society of Anaesthesiologist class I and II, Post chemotherapy patients undergoing open ovarian cancer surgery and requiring opioid based patient controlled analgesia

Exclusion Criteria

1. American Society of Anaesthesiologist class III and above,

2. Smokers

3. Cognitive impairment or an active psychiatric condition

4. Patients with known liver and kidney diseases,

5. History of a palanosetron/ ondansetron/ dexamethasone or fentanyl allergy

6. Use of corticosteroids, psychoactive drugs or any other medication with known emetic or

antiemetic effect within 24 hrs prior to surgery

7. History of opioid abuse.

Extended Exclusion Criteri

1. Patients who will be shifted to intensive care unit on endotracheal tube for post operative mechanical ventilation

Study & Design

• Study Type: Interventional
• Study Design: Not specified