Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women

Not Applicable

Completed

• Conditions: Skin Manifestations; Skin Wrinkling
• Interventions: Dietary Supplement: placebo (starch); Dietary Supplement: CTP

• Registration Number: NCT03505684
• Lead Sponsor: Pusan National University Yangsan Hospital

Brief Summary

Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants

Detailed Description

The aim is to investigate the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants by a randomized, double-blind, and control-group study.

Study Timeline

• Study Start: 2017-12-24
• Study First Submitted: 2018-04-13
• Study First Submitted QC: 2018-04-20
• Study First Posted: 2018-04-23
• Primary Completion: 2018-07-15
• Study Completion: 2018-07-30
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-27
• Last Update Posted: 2018-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 84

Inclusion Criteria

• > = 4 of Tewameter

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Exclusion Criteria

• Within the last 6 months, took skin surgery including cosmetic purpose
• Diabetic patients with poor glycemic control with a fasting blood glucose of 160 mg/dl or more
• Creatinine levels: more than twice the normal upper limit
• AST (GOT) or ALT (GPT) levels: more than twice the normal upper limit
• Uncontrolled hypertension
• sun allergy or sensitive skin
• functional cosmetics that affect dermal moistures and wrinkles within the last 3 months.
• If you have participated or are planning to participate in another clinical trial within the past month
• Alcohol abuser
• If they are pregnant or lactating or have a pregnancy plan during the clinical trial Those with allergic reactions to the constituent food
• Any person deemed inappropriate by the researcher for other reasons

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	placebo (starch)	1,000 mg of placebo (starch) was orally administered per day for 12 weeks
CTP group	CTP	1,000 mg of collagen tripeptide (CTP) was orally administered per day for 12 weeks.

Primary Outcome Measures

Name	Time	Method
changes in Transepidermal Waterloss by Tewameter	baseline, after 6 weeks, and after 12 weeks	comparison between baseline, after 6 weeks, and after 12 weeks

Secondary Outcome Measures

Name	Time	Method
changes in hydration level of the skin surface by Corneometer	baseline, after 6 weeks, and after 12 weeks	comparison between baseline, after 6 weeks, and after 12 weeks
changes in skin wrinkling indices by Visiometer	baseline, after 6 weeks, and after 12 weeks	comparison between baseline, after 6 weeks, and after 12 weeks
skin elasticity by Cutometer	baseline, after 6 weeks, and after 12 weeks	comparison between baseline, after 6 weeks, and after 12 weeks

Trial Locations

Locations (1)

Integrated Research Institute for Natural Ingredients and Functional Foods; 🇰🇷 Yangsan, Korea, Republic of