Measuring Athletes’ Risk of Cardiovascular Events - Exercise-Induced Cardiac Troponin Release and CoronaryAtherosclerosis in Amateur Athletes
- Conditions
- Coronary atherosclerosis
- Registration Number
- NL-OMON24615
- Lead Sponsor
- Department of Physiology, Radboudumc
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Participation in MARC-2 study (so recent information about coronary atherosclerosis
is known).
- Availability of recent (<2 years) contrast enhanced coronary CT-scan data
- Willingness to be approached for participation in future research (as indicated on the
informed consent form of the MARC-2 study)
- Able to perform a ±1.5 hour exercise test on a bicycle
- Unable to give informed consent
- Presence of a stent in any coronary artery or undergone coronary artery bypass
surgery
- Not cleared for exercise training by a cardiologist following the MARC-2 study
coronary CT-scan findings
- Absolute contra-indications for an exercise test (as indicated by the Standard
Operating Procedure guidelines of the department of Physiology)
- Participation in an interventional study targeting cardiovascular health
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary aim of this explorative study is to compare exercise-induced cardiac<br>troponin elevations between athletes with different levels of coronary atherosclerosis.
- Secondary Outcome Measures
Name Time Method The<br>secondary aim is to compare exercise responses to other cardiac biomarkers across<br>subgroups, whereas physiological and biochemical responses are assessed to gain more<br>insight in the potential underlying mechanisms of accelerated coronary atherosclerosis in<br>amateur athletes.