The Prospective Athlete Heart Study- elucidating genetic determinants of cardiac remodelling using endurance exercise as an environmental stress.

Not Applicable

Recruiting

• Conditions: Cardiac Remodelling; Athlete's Heart; Heart Failure; Genetics; Cardiac arrythmia's; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12618000716268
• Lead Sponsor: Baker Heart and Diabetes Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-01
• Last Update Posted: 7 September 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 480

Inclusion Criteria

Endurance athletes, male and female, aged 16-23 years, competing in endurance sports in which aerobic fitness conditioning is a principal component of performance. Aiming to be involved in competition and high level training for more than 5 years.
Non-athletes, male and female, aged 16-23 years, less than 2 hours of endurance activity per week, not competing in an endurance sport, not enrolled in a fitness program to improve fitness.

Exclusion Criteria

-Known cardiovascular disease
-Cigarette smoking (current or previous)
-Moderate or severe hypertension.
-Use of performance enhancing drugs.
-A contraindication to magnetic resonance imaging

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assess the prevalence of rare variants in cardiac structural genes relative to Left Ventricular Mass index in endurance athletes and non-athletes by performing next generation sequencing in 65 cardiac genes extracting DNA from circulating white cells.[2 years after baseline testing];left ventricular mass index (LVMi) on cardiac magnetic resonance imaging (CMR) [2 years after baseline testing]