Measuring Athletes* Risk of Cardiovascular Events - Exercise-Induced Cardiac Troponin Release and Coronary Atherosclerosis in Amateur Athletes

Completed

Conditions: 10011082
coronary artery disease
Coronary atherosclerosis

Registration Number: NL-OMON49634

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

- Participation in MARC-2 study (so recent information about coronary
atherosclerosis is known).
- Availability of recent (<2 years) contrast enhanced coronary CT-scan data
- Willingness to be approached for participation in future research (as
indicated on the informed consent form of the MARC-2 study)
- Able to perform a ±1.5 hour exercise test on a bicycle

Exclusion Criteria

- Unable to give informed consent
- Presence of a stent in any coronary artery or undergone coronary artery
bypass surgery
- Not cleared for exercise training by a cardiologist following the MARC-2
study coronary CT-scan findings
- Absolute contra-indications for an exercise test (as indicated by the
Standard Operating Procedure guidelines of the department of Physiology (see
page 16 of C1 protocol)).
- Participation in an interventional study targeting cardiovascular health

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is cardiac troponin concentration at 0/30/60/120 and 180<br /><br>minutes after exercise cessation. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints are other cardiac biomarkers (B-type natriuretic peptide,<br /><br>soluble ST-2, cardiac myosin-binding protein C and Galectin-3) collected at the<br /><br>same timepoints. Furthermore, exercise-specific physiological parameters<br /><br>(including blood pressure, saturation and heart rate), biochemical biomarkers<br /><br>(calcium, parathyroid hormone, phosphate and magnesium) and measures of<br /><br>vascular function (Carotid Artery Reactivity test) are collected to gain more<br /><br>insight into the potential underlying mechanisms of accelerated coronary<br /><br>atherosclerosis in amateur athletes. </p><br>