Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol

Phase 4

Completed

• Conditions: Hyperthyroidism
• Interventions: Drug: Propanolol

• Registration Number: NCT03393728
• Lead Sponsor: Yaounde Central Hospital

Brief Summary

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.

Detailed Description

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours. Other outcomes included mean heart rate, mean R-R interval during 2-hour rest.

The study questions the systematic adjunction of Propanolol early in the treatment of hyperthyroidism.

Study Timeline

• Study Start: 2008-09-01
• Primary Completion: 2008-12-30
• Study Completion: 2009-09-30
• Study First Submitted: 2017-12-21
• Status Verified: 2018-01
• Study First Submitted QC: 2018-01-05
• Last Update Submitted: 2018-01-05
• Study First Posted: 2018-01-08
• Last Update Posted: 2018-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• consenting patients referred to or diagnosed at the National Centre of Obesity of the Yaounde Central Hospital as having hyperthyroidism
• naïve of all treatment specific for hyperthyroidism.
• aged 18-70 years

Exclusion Criteria

• Patients already under a specific treatment for hyperthyroidism
• Patients taking beta blockers or any other cardiospecific treatment
• Patients presenting complications including acute thyrotoxic crisis, or symptomatic cardiac failure
• Contraindications to the prescription of beta blockers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Intervention	Propanolol	72-hour propanolol before specific treatment of hyperthyroidism

Primary Outcome Measures

Name	Time	Method
Heart rate variability	72 hours	Sympatho vagal tone measures

Secondary Outcome Measures

Name	Time	Method
Heart rate	72 hours	Heart rate