Restrictive fluid management and early fluid de-escalation versus usual care In critically ill patients: A feasibility Randomized Controlled Trial.

/A0 个研究点目标入组 100 人开始时间: 2022年7月19日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•1. The patient who is 18 years of age or older
•2. The patient with circulatory shock who need fluid resuscitation or vasopressor
•3. The patient has been in intensive care unit for at least 12 hours but no more than 72 hours

•1. The patient with hypovolemic shock or hemorrhagic shock
•2. The patient with active bleeding requiring blood transfusion
•3. The patient who has severe AKI (KDIGO stage3)
•4. The patient who is expected to initiate RRT within 24 hour
•5. The patient who receives chronic RRT (maintenance dialysis or renal transplant)
•6. The patient who needs maintenance fluid therapy (e.g. diabetic ketoacidosis, non-ketotic coma)
•7. The patient with third space loss from severe ascites, severe burn, or bowel obstruction
•8. Severe hyponatremia (Na <125mmol/L) or hypernatremia (Na >155mmol/L)
•9. Congestive heart failure
•10. Decompensated cirrhosis
•11. Severe hypoalbuminemia (serum albumin < 2.0 g/dL)
•12. The patient with ongoing gastrointestinal loss (e.g. persistent diarrhea)
•13. The patient with ongoing fluid loss from drainage (more than 500 ml within 8 hours)
•14. The patient with symptomatic fluid overload after fluid resuscitation
•15. Pregnancy or lactation
•16. Patient who receives palliative care
•17. Furosemide allergy

发起方