TCTR20220719002
Unknown
Phase 2
Restrictive fluid management and early fluid de-escalation versus usual care In critically ill patients: A feasibility Randomized Controlled Trial.
/A0 sites100 target enrollmentJuly 19, 2022
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Critically ill adult patients with circulatory shock requiring fluid resuscitation or vasopressors
- Sponsor
- /A
- Enrollment
- 100
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. The patient who is 18 years of age or older
- •2\. The patient with circulatory shock who need fluid resuscitation or vasopressor
- •3\. The patient has been in intensive care unit for at least 12 hours but no more than 72 hours
Exclusion Criteria
- •1\. The patient with hypovolemic shock or hemorrhagic shock
- •2\. The patient with active bleeding requiring blood transfusion
- •3\. The patient who has severe AKI (KDIGO stage3\)
- •4\. The patient who is expected to initiate RRT within 24 hour
- •5\. The patient who receives chronic RRT (maintenance dialysis or renal transplant)
- •6\. The patient who needs maintenance fluid therapy (e.g. diabetic ketoacidosis, non\-ketotic coma)
- •7\. The patient with third space loss from severe ascites, severe burn, or bowel obstruction
- •8\. Severe hyponatremia (Na \<125mmol/L) or hypernatremia (Na \>155mmol/L)
- •9\. Congestive heart failure
- •10\. Decompensated cirrhosis
Outcomes
Primary Outcomes
Not specified
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