eurological and neuropsychological sequelae of Covid-19 infectio

Completed

• Conditions: 10029305; 10024970; corona disease; Covid-19 infection

• Registration Number: NL-OMON55029
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 430

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:

Patients:
- Objectified COVID-19 infection for which ICU or hospital admission was
necessary at one of the participating hospitals
- Age > 18 years
- Sufficient command of the Dutch language to follow test instructions and
understand questionnaires
- Informed consent.

Primary caregivers (if present):
- Primary caregiver (spouse or close family member who takes care of the
patient most) of a participant with COVID-19 infection as described above
- Age > 18 years
- Sufficient command of the Dutch language to understand questionnaires
- Informed consent.

Patients subgroup second/third wave :
- Objectified COVID-19 infection for which ICU or non-ICU hospital admission
was necessary at the MUMC+one of the participating hospitals
- Age > 18 years
- Sufficient command of the Dutch language to follow test instructions and
understand questionnaires
- Informed consent
- Treated with both dexamethasone and tocilizumab during ICU admission.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:

Patients:
- objectified cognitive impairments before the hospital admission for the
COVID-19 infection
- an unexpected incident leading to severe neurological damage occurring after
hospital discharge (such as stroke or traumatic brain injury)
- contra-indications for MRI scanning (e.g. metal implants, cardiac pacemaker,
claustrophobia, pregnancy)
-- physical inability to independently travel to one of the participating
hospitals (e.g., bedridden patients).

Primary caregivers: no exclusion criteria.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Patient-related outcome: participation and quality of life. Caregiver-related<br /><br>outcome: caregiver burden and quality of life. Neurological outcome: MRI<br /><br>abnormalities and neurological symptoms. Neuropsychological outcome: global and<br /><br>domain-specific deficits in cognitive functioning. Emotional outcome: mood and<br /><br>impact of event. Secondary outcomes: subjective complaints in several areas of<br /><br>functioning.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>