The glycemic index of different grain based foods in healthy volunteers.

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 14

Inclusion Criteria

• Blood pressure: diastolic blood pressure between 60 and 90 mmHg and a systolic
blood pressure between 100 and 150 mmHg
• Body Mass Index (BMI; weight/length2) between 18 and 25 kg/m2
• Protein and glucose are not allowed to be present in urine that will be collected
during screening.
• Subjects have to be healthy (self reported) and are not allowed to use medication
that can interfere with the current study.
• Normal Dutch dietary eating habits (no vegan, vegetarian or macrobiotic lifestyle)

Exclusion Criteria

• Having a history of medical or surgical events that may significantly affect the
study outcome (gastro-intestinal diseases)
• Any current metabolic or endocrine disease
• Diabetes Mellitus (type I and II)
• More than 28 consumptions of alcohol a week (for men) and more than 21 consumptions of alcohol a week (for women)
• Reported intolerance for gluten
• Having regularly gastro-intestinal complaints (stomach upsets, diarrhea, constipation, wind, abdominal colic)
• Reported unexplained weight loss or gain of >2kg in the month prior to the pre-study screening
• Reported slimming or medically prescribed diet
• Reported vegan, vegetarian or macrobiotic lifestyle
• Use of antibiotics during the last three months
• Pregnant or lactating or wishing to become pregnant in the period of the study
• currently in menopause / post-menopausal
• The following drugs are not allowed during the study:
1. Anti-hypertensive drugs
2. Lipid lowering-drugs
3. Glucose-lowering agents.
4. Anti-inflammatory agents
5. Chronic oral or parenteral corticosteroids treatment (> 7 consecutive days of treatment).
6. Laxatives, antibiotics, anti-diarrhea drugs

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Blood glucose response after consumption of the test products (2 grain-based<br /><br>baked food products and white bread).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Related effects (of the glucose responses) on subjective ratings of hunger and<br /><br>satiety.<br /><br><br /><br>Correlation between the obtained in vivo data and in vitro digestion data<br /><br>resulting from trials at TNO-Zeist.</p><br>