GB491 Combined With Fulvestrant for HR+ HER2- Locally Advanced or Metastatic Breast Cancer
- Conditions
- Locally Advanced or Metastatic Breast Cancer
- Interventions
- Drug: Placebo+Fulvestrant
- Registration Number
- NCT05054751
- Lead Sponsor
- Genor Biopharma Co., Ltd.
- Brief Summary
GB491-004 is a multicenter, randomized, double-blind, placebo-controlled Phase III study to evaluate the efficacy and safety of GB491 in combination with fulvestrant in patients with HR-positive, HER2-negative locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 275
- Females or males of 18 years of age or older and less than 75 years of age at study screening
- Histologically or cytologically confirmed locally advanced or metastatic breast cancer that is not amenable to curative surgical resection or radiation therapy
- Patients have been diagnosed with ER-positive breast cancer in the local laboratory
- Patents have been diagnosed with HER2-negative breast cancer in the local laboratory
- Menopausal status is not limited (including Premenopausal/perimenopausal/postmenopausal state)
- Prior endocrine therapy and chemotherapy, the following are permitted:
- Prior endocrine adjuvant therapy: a) Radiologic evidence of progressive disease (PD) during or within 12 months following (neo)adjuvant therapy with an aromatase inhibitor (AI) or an anti-estrogen such as tamoxifen, and no subsequent endocrine therapy for locally advanced or metastatic breast cancer; b) Radiologic evidence of PD during or within 12 months following (neo)adjuvant therapy with an AI or an anti-estrogen such as tamoxifen, after receiving the first-line endocrine therapy for locally advanced or metastatic breast cancer, and who developed radiologically documented PD after receiving therapy for ≥ 6 months; c) Radiologically documented PD more than 12 months following the end of adjuvant therapy with AIs or anti-estrogens such as tamoxifen, followed by radiographic progression following first-line therapy with AIs or anti-estrogens for locally advanced or metastatic breast cancer; 2) Progression with radiographic evidence of disease following prior first-line endocrine therapy for locally advanced or metastatic breast cancer in subjects who have not received prior (neo) adjuvant therapy; 3) Prior chemotherapy: In addition to endocrine therapy, subjects are eligible if they received a maximum of 1 prior line of chemotherapy for locally advanced or metastatic breast cancer and discontinued treatment for at least 28 days prior to randomization; 7.According to RECIST V1.1, the patient has at least one measurable lesion that has not been irradiated by radiotherapy and can be evaluated by CT/MRI; If there is no measurable lesion, there must be at least one osteolytic bone lesion that can be evaluated by CT/MRI 8.ECOG performance status of 0 or 1 9.Adequate organ and marrow function.
Key
- Previous treatment with fulvestrant, everolimus or any other CDK4/6 inhibitors
- Patients with known hypersensitivity to any component of GB491 or Fulvestrant
- Known active, uncontrolled, or symptomatic central nervous system metastasis, carcinomatous meningitis, or clinically manifested leptomeningeal disease, cerebral edema, spinal compression or/and tumor progressive growth
- Visceral crisis
- Patients with skin lesion only and radiographically non-measurable at baseline
- Persistent toxicities (CTCAE Grade >2) caused by previous anticancer therapy, excluding alopecia
- Patients who have been on bisphosphonates and denosumab therapy at a stable dose for less than 7 days prior to randomization
- Patients who have received limited field radiotherapy in 2 weeks or extended field radiotherapy in 4 weeks before randomization or radiation with more than 30% of the bone marrow
- Patients use drugs or fruits containing strong inducers or inhibitors of CYP3A4/5, or drugs with narrow therapeutic window that are mainly metabolized by CYP3A4/5 in 14 days before randomization
- Patients with long-term systematic use of corticosteroids
- Any severe and/or uncontrollable medical conditions
- Patients with severely impaired lung function
- Known history of HIV infection or history of HIV seropositivity
- Patients have significant hepatic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description GB491+ Fulvestrant GB491+ Fulvestrant - Placebo+Fulvestrant Placebo+Fulvestrant -
- Primary Outcome Measures
Name Time Method PFS assessed by the investigator Approximately 1.5 years To assess the PFS assessed by the investigator
- Secondary Outcome Measures
Name Time Method DCR Approximately 1.5 years To assess the disease control rate
CBR Approximately 1.5 years To assess the clinical benefit rate
Safety and tolerability Approximately 3 years To assess the safety and tolerability assessed by incidence and severity of adverse events (AEs) and serious AEs (SAEs) according to NCI-CTCAE version 5.0
PK From Cycle 1 to Cycle 4, approximately 4 months To assess the PK assessed by population pharmacokinetic analysis based on plasma concentrations of GB491
PFS assessed by the blinded independent central review (BICR) Approximately 1.5 years To assess the PFS assessed by the BICR
OS Approximately 3 years To assess the overall survival (OS)
ORR Approximately 1.5 years To assess the objective response rate (ORR)
DOR Approximately 1.5 years To assess the duration of response
Trial Locations
- Locations (54)
The First Affiliated Hospital of Bengbu Medical College
🇨🇳Bengbu, Anhui, China
Anhui Provincial Cancer Hospital
🇨🇳Hefei, Anhui, China
The Second Hospital of Anhui Medical University
🇨🇳Hefei, Anhui, China
Beijing Chaoyang Hospital of Capital Medical University
🇨🇳Beijing, Beijing, China
Cancer hospital Chinese Academy of Medical Sciences
🇨🇳Beijing, Beijing, China
Chinese PLA General Hospital
🇨🇳Beijing, Beijing, China
Beijing Tiantan Hospital , Capital Medical University
🇨🇳Beijing, Beijing, China
Chongqing University Cancer Hospital
🇨🇳Chongqing, Chongqing, China
The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
Chognqing University Three Gorges Hospital
🇨🇳Chongqing, Chongqing, China
Scroll for more (44 remaining)The First Affiliated Hospital of Bengbu Medical College🇨🇳Bengbu, Anhui, China