The effectiveness of propranolol in difficult to control blood pressure - a randomized trial
- Conditions
- Resistant hypertension
- Registration Number
- SLCTR/2016/002
- Lead Sponsor
- ational Research Council, Sri Lanka
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
1. Age between 18-75 years
2. Resistant hypertension is defined as casual blood pressure during clinical examination of more than 140/90 mmHg (a mean of the 2nd and 3rd measurements during a single examination, at least 3 min apart) despite treatment with a multidrug combination consisting of a diuretic and ACEI/ARB, centrally acting drug, alpha blocker or calcium channel blocker
3. Blood pressure >140/90mmHg in patients below 60 years and >150/90mmHg if above 60 years
1. Systolic blood pressure > 220mmHg requiring immediate adjustments to therapy
2. Moderate to severe renal insufficiency (acute or chronic) with glomerular filtration rate of less than 30 ml/min ,
3. Active bronchospastic disorders
4. Heart failure class III and IV
5. Severe bradycardia(HR<50bpm)
6. AV block 2 and 3 degrees
7. Women who are lactating or pregnant ( a pregnancy test will be carried out during the initial examination)
8. History of hypersensitivity to any of the drugs under study
9. Current use of beta blockers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method