Strain Analysis as a Right Ventricle Contractility Marker
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 4
- 主要终点
- Evaluation of the change in the Longitudinal strain of the free wall right ventricle
研究概览
简要总结
The analysis of the systolic function (contractility) of the right ventricle (RV) is fundamental and central in many pathologies in intensive care unit. It can guide physicians in choosing therapeutics. The conventional ultrasound markers of RV function evaluation currently used are influenced by RV loading conditions, impairing their capacity to approximate a true contractility analysis. Myocardial strain imaging is a recent echographic technique that allows, among other things, to evaluate RV systolic function. It is a reproducible index with early variations which, if it proved to be independent pre-load, would help to better appreciate the RV contractility.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female ≥ 18 years
- •Patients with renal failure treated with intermittent hemodialysis
- •Patients who received an information and did not opposed to participate in the study, or, if unconscious patient at the time of inclusion: a person of trust as defined in Article L. 1111-6 of the Public Health Code, failing that, the family or, failing that, a person maintaining stable link, having received information and not opposed to participate in the study.
排除标准
- •Patients with heart disease (valvular, ischemic, rhythmic)
- •Patients with ejection fraction of left ventricular altered <45%
- •Chronic dialysis patients
- •Patients referred in Articles L. 1121-5, L.1121-6, L.1121-7, L.1121-8 of the Public Health Code:
- •Pregnant women, parturients or nursing mothers
- •Persons deprived of their liberty by a judicial or administrative decision, persons subject to psychiatric care, persons admitted to a health or social institution for purposes other than research
- •Minor Patients
- •Major persons who are subject to a legal protection measure or are unable to express their consent
- •Patients not willing to participate in the study
- •Patients not affiliated to a social security
研究组 & 干预措施
ultrasound measurements
ultrasound measurements of myocardial deformation of free wall right ventricle during a sharp decline of right ventricle preload induced during a session of Intermittent hemodialysis.
干预措施: ultrasound measurements (Procedure)
结局指标
主要结局
Evaluation of the change in the Longitudinal strain of the free wall right ventricle
时间窗: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
次要结局
- Evaluation of the change in S' right ventricle wave(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)
- Evaluation of the change in tricuspid annular plane systolic excursion (TAPSE)(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)
- Evaluation of the change in visual left ventricular ejection fraction (LVEF)(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)
- Evaluation of the change in mitral E wave(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)
- Evaluation of the change in mitral A wave(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)
- Evaluation of the change in wave E ' at the lateral mitral ring(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)
- Evaluation of the change in systolic fraction of pulmonary venous flow(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)
- inter individual variability of Longitudinal strain of the free wall right ventricle(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)
- intra individual variability of Longitudinal strain of the free wall right ventricle(at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution)