Long-term Paired Associative Stimulation as a Treatment for Incomplete Spinal Cord Injury of Non-traumatic Origin

Not Applicable

Completed

• Conditions: Spinal Cord Injuries; Spinal Cord Diseases
• Interventions: Device: long-term paired associative stimulation

• Registration Number: NCT03104803
• Lead Sponsor: Helsinki University Central Hospital

Brief Summary

The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete SCI of non-traumatic origin.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-03-31
• Study First Submitted: 2017-04-01
• Study First Submitted QC: 2017-04-01
• Study First Posted: 2017-04-07
• Primary Completion: 2018-05-27
• Study Completion: 2018-10-30
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-23
• Last Update Posted: 2019-09-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• incomplete SCI of non-traumatic origin

Exclusion Criteria

• epilepsy
• metal inclusion in the head area
• pacemaker
• hearing device
• high intracranial pressure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Long-term PAS	long-term paired associative stimulation	The intervention is given to one hand only

Primary Outcome Measures

Name	Time	Method
Daniels and Worthingham's Muscle Testing	1 month after the last stimulation session	each hand muscle is evaluated on 0-5 scale

Trial Locations

Locations (1)

BioMag laboratory; 🇫🇮 Helsinki, Finland