Bone Disease in Severely Burned Children
Phase 2
Terminated
- Conditions
- Burn
- Interventions
- Registration Number
- NCT00591162
- Brief Summary
Bone metabolism is adversely affected by severe burns in children for a period of time.
- Detailed Description
More closely monitored biochemical and radiologic parameters of bone and mineral metabolism will increase the likelihood of earlier detection of abnormalities and possible therapeutic interventions.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 254
Inclusion Criteria
- Children age 5-18 years old with at least 40% or more of their body burned.
Exclusion Criteria
- Anyone with a burn covering less than 40% of the body or whose burn covers the front of both hipbones.
- Anyone younger than 5 years old, anyone with a history of cancer or other metabolic disease process, or anyone who is pregnant or has an allergy to Tetracycline will also be excluded.
- Anyone who has participated in an investigational drug trial within the past 60 days from date of admission will be excluded from this study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 Tetracycline Compare bone density of severly burned children to normal non-burned population 1 Duel Energy X-Ray Absorptiometry (DEXA) Compare bone density of severly burned children to normal non-burned population 1 Bone Biopsy Compare bone density of severly burned children to normal non-burned population
- Primary Outcome Measures
Name Time Method Determine Bone Health(bone growth,strength,and content) in burn injured patients. Admission to Burn Unit up to eighteen years old.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
U.T.M.B.
🇺🇸Galveston, Texas, United States