Induction Agent and Incidence of Hypotension in Heart Failure Patients Undergoing LVAD-Implantation
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 主要终点
- Post-Induction hypotension
研究概览
简要总结
The induction of anesthesia is one of the most critical situations for high-risk-patients undergoing major surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this phase.
This observational study aims to find out if the choice of the induction agent has a major impact on blood pressure and the use of antihypotensive drugs during the induction and the surgical procedure in heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Heart failure patients scheduled for implantation of left ventricular assist device (LVAD)
排除标准
- •Pregnancy
- •Presence of another cardiac assist device in the patient (for example ECLS)
- •No consent of the patient
研究组 & 干预措施
Patients undergoing Implantation of left ventricular assist device (Etomidate)
High-risk heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD). The induction agent is etomidate.
干预措施: Etomidate (Drug)
Patients undergoing Implantation of left ventricular assist device (Midazolam)
High-risk heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD). The induction agent is midazolam.
干预措施: Midazolam (Drug)
Patients undergoing Implantation of left ventricular assist device (Sevoflurane)
High-risk heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD). The induction agent is sevoflurane.
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Post-Induction hypotension
时间窗: First 30 minutes after induction of anesthesia
The incidence of hypotension in the first 30 minutes after the induction of anesthesia
次要结局
- Length of stay on the intensive care unit (ICU)(After the procedure and transport to intensive care unit, total time in hours until submission from I. Expected time frame is 48 to 96 hours.CU)
- Antihypotensive drugs during the procedure(Begin of the procedure until end of the procedure)
- Kidney(First 28 days after procedure)
- Antihypotensive drugs after induction(First 30 minutes after induction of anesthesia)
- Mortality(First 28 days after procedure)
- Delirium(First 24 hours after the end of the procedure)
研究者
Dr. Adrian Stephan
Principal Investigator
Heidelberg University