Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation
- Conditions
- Kidney InjuryAdult Respiratory Distress SyndromeAcute Lung Injury
- Interventions
- Device: Airway Pressure Release Ventilation (APRV) modeDevice: Volume-Cycled Assist-Control (AC) mode
- Registration Number
- NCT00793013
- Lead Sponsor
- University of Tennessee, Chattanooga
- Brief Summary
Traditional modes of ventilation have failed to improve patient survival. Subsequent observations that elevated airway pressures observed in traditional forms of ventilation resulted in barotrauma and extension of ALI lead to the evolution of low volume cycled ventilation as a potentially better ventilatory modality for ARDS. Recent multicenter trials by the NIH-ARDS network have confirmed that low volume ventilation increases the number of ventilatory free days and improves overall patient survival. While reducing mean airway pressure has reduced barotrauma and improved patient survival, it has impaired attempts to improve alveolar recruitment. Alveolar recruitment is important as it improves V/Q mismatch, allows reduction in FIO2 earlier, and decreases the risk of oxygen toxicity. Airway pressure release ventilation (APRV) is a novel ventilatory modality that utilizes controlled positive airway pressure to maximize alveolar recruitment while minimizing barotrauma. In APRV, tidal ventilation occurs between the increase in lung volumes established by the application of CPAP and the relaxation of lung tissue following pressure release. Preliminary studies have suggested that APRV recruits collapsed alveoli and improves oxygenation through a restoration of pulmonary mechanics, but there are no studies indicating the potential overall benefit of APRV in recovery form ALI/ADRS.
- Detailed Description
Low volume ventilation may increase number of ventilatory free days and may improve overall patient survival. While reducing mean airway pressure has reduced barotrauma and improved patient survival, it has impaired attempts to improve alveolar recruitment. Alveolar recruitment is important as it improves V/Q mismatch, allows reduction in FIO2 earlier, and decreases the risk of oxygen toxicity. Airway pressure release ventilation (APRV) is a novel ventilatory modality that utilizes controlled positive airway pressure to maximize alveolar recruitment while minimizing barotrauma. In APRV, tidal ventilation occurs between the increase in lung volumes established by the application of CPAP and the relaxation of lung tissue following pressure release. Preliminary studies have suggested that APRV recruits collapsed alveoli and improves oxygenation through a restoration of pulmonary mechanics, but there are no studies indicating the potential overall benefit of APRV in recovery form ALI/ADRS.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- All patients admitted to the Internal Medicine service at the Baroness Erlanger Hospital of the University of Tennessee College of Medicine with hypoxia (O2 saturation < 93%) and pulmonary distress, will be screened for study participation.
- Patients displaying all the following clinical criteria: acute onset of respiratory failure; hypoxia defined as a PaO2/FiO2 ratio of < 300 Torr; pulmonary capillary wedge pressure less or equal than 18 mm Hg, and/or no clinical evidence of left sided heart failure; and chest x-ray with diffuse bilateral pulmonary infiltrates.
- Patients receiving conventional volume ventilation with or without PEEP for > 6 hours prior to study enrollment
- Patient's family or surrogate unwilling to give informed consent
- Patients requiring sedation or paralysis for effective ventilation
- Patients known pulmonary embolus within 72 hours of study enrollment
- Patients with close head injuries or evidence of increased intracranial pressure
- Patients with burns over 30% of total body surface area
- Pulmonary capillary wedge pressure greater than 18 mm Hg
- CVP > 15 cm H2O
- Patients with B type Naturetic peptide levels > 1000
- Patients with prior history of dilated cardiomyopathy with EF < 25%
- Patients receiving chronic outpatient peritoneal or hemodialysis
- Patients with severe liver disease (as defined by Child-Pugh class C)
- AIDS patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description APRV Ventilation Airway Pressure Release Ventilation (APRV) mode - ARDS Net Low Tidal Volume Volume-Cycled Assist-Control (AC) mode -
- Primary Outcome Measures
Name Time Method All cause mortality 28 days or prior to hospital discharge
- Secondary Outcome Measures
Name Time Method Number of ventilator-free days 28 days or prior to hospital discarge To determine the effects of APRV ventilation versus ARDS net low volume-cycle ventilation on the incidence of of AKI 28 days or prior to hospital discharge To determine the effects of APRV ventilation versus ARDS net low volume-cycle ventilation on the NGAL, KIM-1, and IL-18 urine biomarkers for AKI 28 days or prior to hospital discharge To determine the effects of APRV ventilation versus ARDS net low volume-cycle ventilation in maintaining hourly urine output > 0.5 mls/kg/hr 28 days or prior to hospital discharge Length of ICU stay and /or Total hospital days 28 days or prior to hospital discharge Will determine urinary aquaporin-2 levels in patients randomized to APRV ventilation versus ARDS net low volume-cycle ventilation 28 days or prior to hospital discharge
Trial Locations
- Locations (1)
James A. Tumlin, MD
🇺🇸Chattanooga, Tennessee, United States