Essential Fatty Acids During Complementary Feeding
Not Applicable
Completed
- Conditions
- ObesityGrowthMetabolic SyndromeCardiovascular Disease
- Interventions
- Dietary Supplement: Fish OilDietary Supplement: Sunflower Oil
- Registration Number
- NCT00631046
- Lead Sponsor
- University of Copenhagen
- Brief Summary
The objective of this intervention study is to examine the effect of n-3 LCPUFA on growth and body composition, intestinal health and microbiotic composition, immune function and risk markers for later diseases in 9-18 months old infants and toddlers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Singleton infants, 9 mo +/- 2 wk, born >= 37 wk of gestation
- Birth weight >=2500g, a 5-min Apgar score >= 7, birth weight >= 5th percentile for gestational age
Exclusion Criteria
- Chronic diseases expected to influence growth and dietary intake
- Use of medicine expected to influence growth and dietary intake
- Fish oil supplementation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fish Oil Fish Oil containing n-3 LCPUFA Sunflower oil Sunflower Oil containing n-6 PUFA
- Primary Outcome Measures
Name Time Method Growth Body composition Intestinal microbiota Blood pressure Plasma lipid profile Insulin - glucose Erythrocyte fatty acid composition Ex vivo cytokine production IGF-1 and IGFBP-3 Adipokines Plasma CRP Plasma IgE
- Secondary Outcome Measures
Name Time Method Glucagon Metagenome analysis (investigating the enzymatic capacity of the intestines through prokaryotic DNA sequencing) Iron status (hemoglobin, ferritin) faecal calprotectin FADS1 and FADS2 genotypes Allergy status
Trial Locations
- Locations (1)
Dept. of Human Nutrition
🇩🇰Copenhagen, Frederiksberg C, Denmark