Intestinal permeability in glomerular diseases
Not Applicable
- Conditions
- N05N00-N08Unspecified nephritic syndromeGlomerular diseases
- Registration Number
- DRKS00021533
- Lead Sponsor
- niversitätsklinikum der RWTH Aachen
- Brief Summary
The present single center pilot study suggests that disturbed intestinal permeability is common in patients with glomerular diseases and is not specific for IgAN.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
Biopsy-proven primary glomerulonephritis or no prior renal disease (healthy controls). Able to consent.
Exclusion Criteria
History of chronic gastrointestinal diseases, signs of acute infection, diabetes mellitus, end-stage renal disease, or intake of non-steroidal anti-inflammatory drugs (NSAID) during the last 48 hours prior to the study as well as pregnant and breast-feeding patients
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rinary excretion of the various sugars (lactulose, L-rhamnose, sucralose and erythritol) at 2, 5, 24 hrs after oral ingestion
- Secondary Outcome Measures
Name Time Method