Is a single dose of prophylactic antibiotics as effective as a three dose regime in preventing post-operative infection in paediatric patients with simple appendicitis?

icole Mennie, BMedSci Student0 个研究点目标入组 300 人开始时间: 2011年8月29日最近更新: 2020年1月13日

试验速览

暂无简介。

•All patients who have their appendix removed and are found on operation to have ‘simple appendicitis’ as defined in the Cochrane review (an appendix that is non-inflamed, acutely inflamed, phlegmonous, suppurative or mildly inflamed).

•-Any patient whose guardian does not wish for them to participate in the study.
•- Patients who on operation are found to have ‘complicated appendicitis’ defined as an appendix that is gangrenous or perforated.
•-Patients who pre-operatively appear to be acutely septic or for another reason require extended antibiotic therapy.
•- Patients who, at operation, are found to have other pathology e.g. Meckel’s Diverticulum, Intussusception; requiring surgical or medical intervention.
•-Patients who have additional co-morbidities, including diabetes, immuno-suppression, cardiac, renal or liver failure.
•- If the child continues to show sign of sepsis, in terms of fever, tachycardia, he/she will be discontinued from the study and be given additional doses of antibiotics, as clinically indicated.

发起方

icole Mennie, BMedSci Student