Is a single dose of prophylactic antibiotics as effective as a three dose regime in preventing post-operative infection in paediatric patients with simple appendicitis?

icole Mennie, BMedSci Student0 sites300 target enrollmentAugust 29, 2011

Overview

No summary available.

Registry

who.int

Start Date

August 29, 2011

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

icole Mennie, BMedSci Student

•All patients who have their appendix removed and are found on operation to have ‘simple appendicitis’ as defined in the Cochrane review (an appendix that is non\-inflamed, acutely inflamed, phlegmonous, suppurative or mildly inflamed).

•\-Any patient whose guardian does not wish for them to participate in the study.
•\- Patients who on operation are found to have ‘complicated appendicitis’ defined as an appendix that is gangrenous or perforated.
•\-Patients who pre\-operatively appear to be acutely septic or for another reason require extended antibiotic therapy.
•\- Patients who, at operation, are found to have other pathology e.g. Meckel’s Diverticulum, Intussusception; requiring surgical or medical intervention.
•\-Patients who have additional co\-morbidities, including diabetes, immuno\-suppression, cardiac, renal or liver failure.
•\- If the child continues to show sign of sepsis, in terms of fever, tachycardia, he/she will be discontinued from the study and be given additional doses of antibiotics, as clinically indicated.