Are post-operative antibiotics indicated in simple appendicitis? A prospective randomized trial.

Phase 4

• Conditions: Simple Appendicitis; Post-operative Infection; Surgery - Other surgery; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12611000919910
• Lead Sponsor: icole Mennie, BMedSci Student

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-08-29
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

All patients who have their appendix removed and are found on operation to have ‘simple appendicitis’ as defined in the Cochrane review (an appendix that is non-inflamed, acutely inflamed, phlegmonous, suppurative or mildly inflamed).

Exclusion Criteria

-Any patient whose guardian does not wish for them to participate in the study.
- Patients who on operation are found to have ‘complicated appendicitis’ defined as an appendix that is gangrenous or perforated.
-Patients who pre-operatively appear to be acutely septic or for another reason require extended antibiotic therapy.
- Patients who, at operation, are found to have other pathology e.g. Meckel’s Diverticulum, Intussusception; requiring surgical or medical intervention.
-Patients who have additional co-morbidities, including diabetes, immuno-suppression, cardiac, renal or liver failure.
- If the child continues to show sign of sepsis, in terms of fever, tachycardia, he/she will be discontinued from the study and be given additional doses of antibiotics, as clinically indicated.

Study & Design

• Study Type: Interventional
• Study Design: Not specified