Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)

Completed

• Conditions: Preeclampsia

• Registration Number: NCT00653809
• Lead Sponsor: University of Mississippi Medical Center

Brief Summary

The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-06
• Study First Submitted: 2008-04-01
• Study First Submitted QC: 2008-04-04
• Study First Posted: 2008-04-07
• Primary Completion: 2008-12
• Study Completion: 2009-09
• Status Verified: 2012-04
• Last Update Submitted: 2012-04-05
• Last Update Posted: 2012-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 52

Inclusion Criteria

• African-american or Caucasian
• Pregnant
• Between ages of 18 - 40 years of age

Exclusion Criteria

• Presence of a disease or condition which is not preeclampsia
• Drug or alcohol abuse during pregnancy
• Obesity

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Nitric oxide and Endothelin-1 levels	48 hours after tissue collection

Secondary Outcome Measures

Name	Time	Method
Nitric oxide isoforms and Endothelin-1 receptor activation based on primary outcome	within 6 months from tissue collection

Trial Locations

Locations (1)

University of MS Medical Center; 🇺🇸 Jackson, Mississippi, United States