TRENDY Follow-up: Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus

Completed

• Conditions: Type 2 Diabetes Mellitus
• Interventions: Drug: Telmisartan 80 mg/d; Drug: Ramipril 10 mg/d

• Registration Number: NCT00905528
• Lead Sponsor: University of Erlangen-Nürnberg Medical School

Brief Summary

Basal nitric oxide (NO) activity plays a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments its alteration has been associated with morphological changes characteristic of diabetic nephropathy. The investigators aimed to assess in a prospective study: 1. basal NO activity of renal vasculature and 2. renal hemodynamics to examine whether impairment of basal NO activity of the renal vasculature is related to development and progression of diabetic nephropathy and other cardiovascular endpoints.

Detailed Description

Not available

Study Timeline

• Study Start: 2002-01
• Primary Completion: 2004-12
• Study Completion: 2004-12
• Study First Submitted: 2009-05-19
• Study First Submitted QC: 2009-05-19
• Study First Posted: 2009-05-20
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-24
• Last Update Posted: 2015-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 69

Inclusion Criteria

• Type 2 Diabetes mellitus

Exclusion Criteria

• Macroalbuminuria
• Symptomatic cardiovascular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A	Telmisartan 80 mg/d	Subjects with type 2 diabetes mellitus, eGFR \> 80, hypertension, no overt proteinuria
B	Ramipril 10 mg/d	Subjects with type 2 diabetes mellitus, eGFR \> 80, hypertension, no overt proteinuria

Primary Outcome Measures

Name	Time	Method
Change in eGFR after 1 year

Trial Locations

Locations (1)

University of Erlangen-Nuremberg; 🇩🇪 Erlangen, Bavaria, Germany