Peripheral arterial disease and its circulating markers that show reflect the causative factors
Phase 1
- Conditions
- Health Condition 1: null- only few healthy volenteers for baseline values (no intervention)
- Registration Number
- CTRI/2018/01/011512
- Lead Sponsor
- AIIMS New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
1.Patients with clinical features suggestive of peripheral arterial disease of lower limbs
2.PAD patients with age >18 years
Exclusion Criteria
1.PAD patients with gangrene of foot proximal to toes (fore foot/foot)
2.Recent history of CAD (within 3 months of screening)
3.Patient diagnosed with malignancy in present or past.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To study the alteration in endothelial Nitric oxide synthase (eNOS), Tumor necrosis factor-alpha (TNF-α), Interferon-gamma (IFN-γ), Interleukin-10, Interleukin-6, Transforming growth factor-beta (TGF-β) and VEGF in patients with peripheral arterial disease as compared to controls. <br/ ><br>2.To study association between the change levels of biomarkers and progression of the disease. <br/ ><br>Timepoint: baseline, one month, two month, three months and six months <br/ ><br>
- Secondary Outcome Measures
Name Time Method To study association between the change levels of biomarkers and progression of the disease. <br/ ><br>Timepoint: Base line, one month two months third month and sixth month after intervention.