Effect of Mental Stress on vascular response in Resistant Hypertensio
Not Applicable
Recruiting
- Conditions
- Essential HypertensionC14.907.489.165
- Registration Number
- RBR-7dghjm
- Lead Sponsor
- niversidade Federal Fluminense
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
40 to 65 years; diagnosis of essential hypertension; adherence to the treatment confirmed; blood pressure of at least 140 to 85 mmHg despite treatment with three anti-hypertensive drugs; blood pressure less than 130 to 85 with the use of four or more antihypertensive drugs.
Exclusion Criteria
Secondary hypertension; diabetes mellitus; stage III, IV and V chronic kidney disease; coronary artery disease; cerebrovascular disease; hepatic insufficiency; ophthalmologic disorders; regular use of nitric oxide donor drugs; stimulators of guanylate cyclase; pregnancy or lactation; current abuse of alcohol or other drugs; severe past drug allergy.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of vascular and hemostatic response to mental stress in patients with resistant hypertension; verified by decreased flow-mediated dilatation, pulse wave velocity, coagulation markers and increased bioavailability of nitric oxide; from the observation of a p value less than or equal to 0.05 in the comparisons of the pre- and post-intervention measurements.
- Secondary Outcome Measures
Name Time Method Difference in the behavior of vascular variables and hemostatic to mental stress among men and women with resistant hypertension; verified by measurements of flow-mediated dilatation, pulse wave velocity, coagulation markers, and bioavailability of nitric oxide; from the observation of a p value less than or equal to 0.05 in the comparisons of the pre- and post-intervention measurements.