A Study of Lebrikizumab in Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
- Registration Number
- NCT01867125
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This randomized, multicenter, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of lebrikizumab in participants with asthma whose disease remains uncontrolled despite daily treatment with inhaled corticosteroid (ICS) therapy and at least one second controller medication. Participants will be randomized in 1:1:1 ratio to receive double-blind treatment with either lebrikizumab ("high" or "low") or placebo, administered subcutaneously (SC) every 4 weeks for 52 weeks, in addition to their standard-of-care therapy. This will be followed by a 52-week double-blind active treatment extension. During double-blind active treatment extension period, all participants will receive SC injection of lebrikizumab from Week 53 to Week 104. The anticipated time on study treatment is 104 weeks. After study treatment, all participants will complete a 20-week safety follow-up.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1081
- Asthma diagnosis for greater than equal to (>/=) 12 months prior to Visit 1
- Bronchodilator response at Visit 1, 2, or 3
- Pre-bronchodilator FEV1 of 40 percent (%) - 80% predicted at both Visits 2 and 3
- On ICS therapy at a total daily dose of 500-2000 micrograms (mcg) of fluticasone propionate dry powder inhaler (DPI) or equivalent for >/=6 months prior to Visit 1
- On an eligible second controller medication (long-acting beta-agonist [LABA], leukotriene receptor antagonist [LTRA], long-acting muscarinic antagonist [LAMA], or theophylline) for 6 months prior to Visit 1
- Uncontrolled asthma at Visit 1 and/or Visit 2, and at Visit 3
- Chest X-ray or computed tomography (CT) scan within 3 months prior to Visit 1 or chest X-ray during the screening period (prior to Visit 3) confirming the absence of other clinically significant lung disease
- Demonstrated adherence with controller medication during the screening period
- History of severe allergic reaction or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the lebrikizumab injection
- Maintenance oral corticosteroid therapy within 3 months of Visit 1
- Treatment with systemic (oral, intravenous [IV], or intramuscular [IM]) corticosteroids within 4 weeks prior to Visit 1 or during the screening period
- Treatment with intra-articular corticosteroids within 4 weeks prior to Visit 1 or during the screening period or anticipated need for intra-articular corticosteroids during the course of the study
- Infection requiring hospital admission for >/=24 hours or requiring treatment with IV or IM antibiotics within 4 weeks prior to Visit 1 or during screening; Upper or lower respiratory tract infection within 4 weeks prior to Visit 1 or during screening; Active infection that required treatment with oral antibiotics within 2 weeks prior to Visit 1 or during screening; Active parasitic infection or Listeria monocytogenes infection within 6 months prior to Visit 1 or during screening
- Active tuberculosis requiring treatment within 12 months prior to Visit 1
- Known immunodeficiency, including, but not limited to, human immunodeficiency virus (HIV) infection
- Evidence of acute or chronic hepatitis or known liver cirrhosis
- History of interstitial lung disease, chronic obstructive pulmonary disease (COPD), or other clinically significant lung disease other than asthma
- Known current malignancy or current evaluation for potential malignancy
- Current smoker or former smoker with a history of greater than (>) 10 pack-years
- History of alcohol or drug abuse
- Past and/or current use of any anti-interleukin (IL)-13 or anti-IL-4/IL-13 therapy, including lebrikizumab
- Use of other monoclonal antibody therapy, including omalizumab, within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer) or during screening
- Initiation of or change in allergen immunotherapy within 3 months prior to Visit 1 or during screening
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Lebrikizumab Participants will receive SC injection of lebrikizumab matching placebo every 4 weeks for 52 weeks during placebo-controlled period and then SC injection of lebrikizumab at 125 or 37.5 mg for 52 weeks during active treatment extension period. Lebrikizumab (37.5 mg) Placebo Participants will receive SC injection of lebrikizumab (37.5 mg) every 4 weeks for 104 weeks. Placebo Placebo Participants will receive SC injection of lebrikizumab matching placebo every 4 weeks for 52 weeks during placebo-controlled period and then SC injection of lebrikizumab at 125 or 37.5 mg for 52 weeks during active treatment extension period. Lebrikizumab (125 mg) Lebrikizumab Participants will receive SC injection of lebrikizumab (125 milligrams \[mg\]) every 4 weeks for 104 weeks. Lebrikizumab (37.5 mg) Lebrikizumab Participants will receive SC injection of lebrikizumab (37.5 mg) every 4 weeks for 104 weeks.
- Primary Outcome Measures
Name Time Method Rate of Asthma Exacerbations During the 52-Week Placebo-Controlled Period Baseline up to 52 weeks
- Secondary Outcome Measures
Name Time Method Absolute Change From Baseline in Pre-Bronchodilator Forced Expiratory Volume in 1 Second (FEV1) Baseline, Week 52 Time to First Asthma Exacerbation Baseline up to 52 weeks Change From Baseline in Standardized Asthma Quality of Life Questionnaire (AQLQ) Score Baseline, Week 52 Change from Baseline In Asthma Rescue Medication (Number of Puffs or Nebulized Treatments) Baseline, Week 52 Rate of Urgent Asthma-Related Urgent Health Care Utilization Baseline up to Week 52 Percentage of Participants With Anti-Therapeutic Antibodies to Lebrikizumab Baseline up to Week 124 (assessed at Baseline, Weeks 4, 12, 24, 36, 52, 64, 76, 92, 104, 112, and 124) Change From Baseline in Asthma Control Questionnaire-5 (ACQ-5) Score Baseline, Week 52 Percentage of Participants With Adverse Events Baseline, Week 124 Minimum Serum Concentration (Cmin) of Lebrikizumab Predose (0 hour) on Weeks 4, 12, 24, 36, and 52
Trial Locations
- Locations (230)
Choc Psf, Amc
🇺🇸Orange, California, United States
North Bay Clinical Trials
🇺🇸Napa, California, United States
Bensch Research Associates
🇺🇸Stockton, California, United States
Laporte County Institute For Clinical Research
🇺🇸Michigan City, Indiana, United States
Waterbury Pulmonary Associates
🇺🇸Waterbury, Connecticut, United States
Allergy & Asthma Care of FL; Clinical Research
🇺🇸Ocala, Florida, United States
Infusion Associates
🇺🇸Grand Rapids, Michigan, United States
Asthma & Allergy Center, P.C.
🇺🇸Papillion, Nebraska, United States
Northeast Medical Research Associates, Inc
🇺🇸North Dartmouth, Massachusetts, United States
Atlanta Allergy & Asthma Clini
🇺🇸Woodstock, Georgia, United States
Atlantic Research Center, LLC
🇺🇸Ocean City, New Jersey, United States
Liverpool Hospital
🇦🇺Liverpool BC, New South Wales, Australia
Fundación Faicep
🇦🇷Buenos Aires, Argentina
Iowa Clinical Research Corporation
🇺🇸Iowa City, Iowa, United States
North Shore University Hosp
🇺🇸New Hyde Park, New York, United States
Asthma & Allergy Center
🇺🇸Toledo, Ohio, United States
Asthma Allergy Phys of RI
🇺🇸Lincoln, Rhode Island, United States
Instituto Ave Pulmo
🇦🇷Mar Del Plata, Argentina
Tekton Research Inc
🇺🇸Austin, Texas, United States
Kaplan Medical Center
🇮🇱Rehovot, Israel
Schonffeldt y Guerrero Limitada
🇨🇱Santiago, Chile
Allergy & Asthma Research of Nj, Inc
🇺🇸Mount Laurel, New Jersey, United States
PMG Research of Wilmington
🇺🇸Wilmington, North Carolina, United States
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi Di Ancona
🇮🇹Torrette - Ancona, Marche, Italy
A.o. Universitaria Pisana; Dipartimento Cardio Toracico
🇮🇹Pisa, Toscana, Italy
Yokohama City Minato Red Cross Hospital
🇯🇵Kanagawa, Japan
Kochi Medical School Hospital
🇯🇵Kochi, Japan
TTS Research
🇺🇸Boerne, Texas, United States
Takahashi Clinic
🇯🇵Kokubunji-shi, Japan
Japan Community Health Care Organization Hokkaido Hospital
🇯🇵Sapporo-shi, Japan
Oki Clinic
🇯🇵Kodaira-shi, Japan
Azienda Ospedaliera di Padova
🇮🇹Padova, Veneto, Italy
Dokkyo Medical University Koshigaya Hospital
🇯🇵Koshigaya-shi, Japan
Centro Médico Dra de Salvo
🇦🇷Buenos Aires, Argentina
Colentina Clinical Hospital
🇷🇴Bucharest, Romania
Tosei General Hospital; Respiratory and Allergy Medicine
🇯🇵Aichi, Japan
Ofuji Clinic
🇯🇵Amagasaki-shi, Japan
National Hospital Organization Mito Medical Center
🇯🇵Higashiibaraki-gun, Japan
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Hopital Nord; CIC
🇫🇷Marseille, France
National Hospital Organization Asahikawa Medical Center
🇯🇵Hokkaido, Japan
Lady Davis Carmel Medical Center; Cardiovascular Medicine
🇮🇱Haifa, Israel
P3 Research
🇳🇿Tauranga, New Zealand
Hospital Dr Angel Leaño universidad Autonoma de Guadalajara AC
🇲🇽Zapopan, Mexico
Russian Uni of People'S Friendship, Med. Faculty; City Clinical Hospital No 64, Internal Diseases
🇷🇺Moscow, Russian Federation
Fondazione Salvatore Maugeri. IRCCS - Divisione di Pneumologia
🇮🇹Cassano Murge (BA), Puglia, Italy
NZ Respiratory & Sleep Institute
🇳🇿Auckland, New Zealand
Ryazan Regional Clinical Hosp
🇷🇺Ryazan, Russian Federation
City Outpatient Dept #94
🇷🇺St Petersburg, Russian Federation
Kyushu Central Hospital
🇯🇵Fukuoka-shi, Japan
Meir Medical Center; Pulmonary Dept
🇮🇱Kfar Saba, Israel
Osaka City University Hospital
🇯🇵Osaka, Japan
Dunedin Hospital
🇳🇿Dunedin, New Zealand
Touda Clinic
🇯🇵Osaka, Japan
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
National Hospital Organization Tokyo National Hospital
🇯🇵Kiyose-shi, Japan
Uludag University; Pulmonology and Allergy Department
🇹🇷Bursa, Turkey
Smolensk State Medical Academy
🇷🇺Smolensk, Russian Federation
Hospital Virgen del Rocio
🇪🇸Sevilla, Spain
St. Petersburg State Budget Medical Institution Pokrovskaya City Hospital
🇷🇺St. Petersburg, Russian Federation
Seoul National University Bundang Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Gatesville Medical Centre
🇿🇦Gatesville, South Africa
Niigata City General Hospital
🇯🇵Niigata-shi, Japan
RMC Medical Research Ltd
🇳🇿Dunedin, New Zealand
Senzoku Kokyuuki and Allergy Clinic
🇯🇵Ota-ku, Japan
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Kinki-Chuo Chest Medical Center
🇯🇵Osaka, Japan
Izmir Dr. Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi
🇹🇷Izmir, Turkey
SIH Kemerovo Regional Clinical Hospital
🇷🇺Kemerovo, Russian Federation
Ege University Medical Faculty
🇹🇷Izmir, Turkey
Castle Hill Hospital; Respiratory Medicine
🇬🇧Cottingham, United Kingdom
Instituto Jalisciense de Investigacion Clinica S.A. de C.V.
🇲🇽Guadalajara, Mexico
Niepubliczny Specjalistyczny ZOZ Puls-Med s.c.
🇵🇱Skarżysko-Kamienna, Poland
Tomsk Regional Clinical Hospital
🇷🇺Tomsk, Russian Federation
Vawda Z.Fa Practice
🇿🇦Durban, South Africa
Central Clinical Hospital #1 of RZhD JCS
🇷🇺Moscow, Russian Federation
SHI Ctr Occupational Pathology
🇷🇺St. Petersburg, Russian Federation
St.-Petersburg SMU n. a. Academician I.P.Pavlov; Therapy Department
🇷🇺Saint-Petersburg, Russian Federation
Turgut Ozal Universitesi Tip Fakultesi Bestepe Hastanesi
🇹🇷Ankara, Turkey
Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi
🇹🇷Canakkale, Turkey
St James University Hospital; Respiratory Department
🇬🇧Leeds, United Kingdom
Hosp Univ Fundacion Alcorcon
🇪🇸Madrid, Spain
Melomed Hospital Gatesville
🇿🇦Cape Town, South Africa
Mersin University Medical Faculty
🇹🇷Mersin, Turkey
Educational Scientific Medical Centre of Donetsk National Medical University;
🇺🇦Donetsk, Ukraine
Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi
🇹🇷Ankara, Turkey
Kirikkale Universitesi Tip Fakultesi Hastanesi
🇹🇷Kirikkale, Turkey
St Peters Hospital
🇬🇧Chertsey, United Kingdom
Ninewells Hospital; Asthma and Allergy Research Group
🇬🇧Dundee, United Kingdom
University North Tees
🇬🇧Teesside, United Kingdom
Municipal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital
🇺🇦Kyiv, Ukraine
Kyiv City Clinical Hospital #8
🇺🇦Kyiv, Ukraine
Allianz Medical and Research Center
🇺🇸Fountain Valley, California, United States
Allergy Medical Clinic
🇺🇸Los Angeles, California, United States
CA Allergy & Asthma Med Grp
🇺🇸Los Angeles, California, United States
Advances in Medicine
🇺🇸Rancho Mirage, California, United States
St. Francis Sleep; Allergy & Lung Institute
🇺🇸Clearwater, Florida, United States
Suncoast Research Group LLC
🇺🇸Miami, Florida, United States
South Florida Research Phase I-IV, Inc
🇺🇸Miami, Florida, United States
Allergy & Asthma Diagnostic; Treatment Center
🇺🇸Tallahassee, Florida, United States
Florida Pulmonary Research Institute, LLC
🇺🇸Winter Park, Florida, United States
Montana Medical Research LLC
🇺🇸Missoula, Montana, United States
Clinical Research Inst. of Southern Oregon, Pc
🇺🇸Medford, Oregon, United States
Asthma Allergy Pulm Associates
🇺🇸Philadelphia, Pennsylvania, United States
Spartanburg Medical Research
🇺🇸Spartanburg, South Carolina, United States
Pharmaceutical Research & Consulting, Inc.
🇺🇸Dallas, Texas, United States
Pioneer Research Solutions
🇺🇸Houston, Texas, United States
O & O Alpan, LLC
🇺🇸Fairfax, Virginia, United States
ASTHMA, Inc
🇺🇸Seattle, Washington, United States
Inspiration Research Limited
🇨🇦Toronto, Ontario, Canada
Albion Finch Medical Centre
🇨🇦Toronto, Ontario, Canada
University of Catanzaro
🇮🇹Catanzaro, Calabria, Italy
The Lung Institute of Western Australia; Sir Charles Gairdner Hospital
🇦🇺Nedlands, Western Australia, Australia
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Allergy Assoc Medical Group
🇺🇸San Diego, California, United States
UCSF School of Medicine
🇺🇸San Francisco, California, United States
Heartland Clinical Research Inc.
🇺🇸Omaha, Nebraska, United States
Allergy & Asthma Associates
🇺🇸Las Vegas, Nevada, United States
Cor Clinical Research
🇺🇸Oklahoma City, Oklahoma, United States
Lynn Health Science Institute
🇺🇸Oklahoma City, Oklahoma, United States
Allergy Associates Research Center
🇺🇸Portland, Oregon, United States
Quality Assurance Research Ctr
🇺🇸San Antonio, Texas, United States
Iwate Medical University Hospital
🇯🇵Iwate, Japan
Tono Chuo Clinic
🇯🇵Mizunami-shi, Japan
Fukuwa Clinic
🇯🇵Tokyo, Japan
Tokyo Center Clinic; Internal Medicine
🇯🇵Tokyo, Japan
Sano Toranomon Clinic
🇯🇵Tokyo, Japan
Showa University Hospital
🇯🇵Tokyo, Japan
Sekino Hospital
🇯🇵Toshima, Japan
Teikyo University Hospital
🇯🇵Tokyo, Japan
CHU Nantes - Hôpital Laennec; Service de Pneumologie
🇫🇷Nantes, France
Hospital Universitario Doctor Peset
🇪🇸Valencia, Spain
Desert Sun Clinical Research LLC
🇺🇸Tucson, Arizona, United States
Alabama Clinical Research Associates
🇺🇸Pell City, Alabama, United States
Clinical Trial Connection
🇺🇸Flagstaff, Arizona, United States
Alliance Research LLC
🇺🇸Long Beach, California, United States
IMMUNOe International Research Centers
🇺🇸Centennial, Colorado, United States
Southeastern Lung Care
🇺🇸Decatur, Georgia, United States
Emerald Coast Research Associates
🇺🇸Panama City, Florida, United States
Midwest Clinical Research LLC
🇺🇸Saint Louis, Missouri, United States
Washington Univ. School of Med
🇺🇸Saint Louis, Missouri, United States
Allergy & Asthma Center of NC
🇺🇸High Point, North Carolina, United States
Princeton Center For Clinical Research
🇺🇸Skillman, New Jersey, United States
Allergy & Asthma Research Grp
🇺🇸Eugene, Oregon, United States
Grand View Hospital; Clinical Research Department
🇺🇸Sellersville, Pennsylvania, United States
Central PA Asth & Allergy Care; Research Division
🇺🇸Altoona, Pennsylvania, United States
Metroplex Pulmonology & Sleep Center
🇺🇸McKinney, Texas, United States
Clinical Research Partners, LLC
🇺🇸Henrico, Virginia, United States
Dean Clinic
🇺🇸Madison, Wisconsin, United States
Bellingham Asthma, Allergy & Immunology
🇺🇸Bellingham, Washington, United States
Centro Respiratorio Quilmes
🇦🇷Quilmes, Argentina
Investigaciones en Patologias Respiratorias
🇦🇷San Miguel de Tucuman, Argentina
Western Hospital
🇦🇺Footscray, Victoria, Australia
Box Hill Hospital; Eastern Clinical Research Unit
🇦🇺Box Hill, Victoria, Australia
St. Vincent's Hospital Melbourne
🇦🇺Fitzroy, South Australia, Australia
Cliniques Universitaires St-Luc
🇧🇪Bruxelles, Belgium
UZ Gent
🇧🇪Gent, Belgium
Dr. E. Amer
🇨🇦Mississauga, Ontario, Canada
Centro de Investigaciones Medicas Respiratorias
🇨🇱Santiago, Chile
Fundacion Neumologica Colombiana
🇨🇴Bogota DC, Colombia
Hospital Carlos Van Buren
🇨🇱Valparaiso, Chile
Interni A Pneumologicka Ambulance
🇨🇿Jindrichuv Hradec, Czechia
MephaCentrum, a.s.
🇨🇿Ostrava - Poruba, Czechia
Alergopraktik s.r.o.
🇨🇿Jablonec Nad Nisou, Czechia
Alergologie Teplice, s.r.o.
🇨🇿Teplice, Czechia
Nouvel Hôpital Civil; Pôle de Pathologie Thoracique
🇫🇷Strabourg, France
Hopital Calmette; Pneumologie
🇫🇷Lille, France
Lungenarztpraxis Tegel
🇩🇪Berlin, Germany
Kenezy Korhaz Rendelointezet
ðŸ‡ðŸ‡ºDebrecen, Hungary
Petz Aladar Megyei Oktato Korhaz
ðŸ‡ðŸ‡ºGyor, Hungary
Oji General Hospital
🇯🇵Hokkaido, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
Nagaoka Red Cross Hospital
🇯🇵Nagaoka-shi, Japan
Poradnia Pulmonologiczna dla Doroslych
🇵🇱Lódz, Poland
University of Fukui Hospital
🇯🇵Yoshida-gun, Japan
Wonju Christian Hospital
🇰🇷Wonju, Korea, Republic of
St. Paul's Hospital, The Catholic University of Korea, College of Medicine
🇰🇷Seoul, Korea, Republic of
Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny
🇵🇱Bialystok, Poland
Klinika Chorób Wewnetrznych i Alergologii MSW
🇵🇱Warszawa, Poland
Dr. Victor Babes Pneumology and Infectious Diseases Clinical Hospital
🇷🇴Timisoara, Romania
St. George the Martyr City Hospital
🇷🇺Saint Petersburg, Russian Federation
St-Petersburg Diagnostic Ctr#1; Pulmonology
🇷🇺St. Petersburg, Russian Federation
Novosibirsk Municipal Clinical Hospital For Emergency Medicine #2
🇷🇺Novosibirsk, Russian Federation
Clinical Hospital Center Zvezdara
🇷🇸Belgrade, Serbia
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Uni of Cape Town Lung Inst.
🇿🇦Cape Town, South Africa
Deepak Lakha MBCHB Private Practice
🇿🇦Johannesburg, South Africa
Dr Johannes Breedt; Emmed Research
🇿🇦Pretoria, South Africa
Hospital Germans Trias i Pujol
🇪🇸Barcelona, Spain
Hospital Universitario Araba
🇪🇸Vitoria, Alava, Spain
Botho ke Bontle Health Services
🇿🇦Pretoria, South Africa
Small Business Private Enterprise Medical Centre Pulse
🇺🇦Vinnytsya, Ukraine
SI Dept. Clin. Hospital of Zaporizhzhia-2 Railway Station of SE Prydniprovska Zaliznytsia
🇺🇦Zaporizhzhia, Ukraine
Municipal Institution of Health Care "Yevpatoriya City Hospital â„–1
🇺🇦Yevpatoriya, Ukraine
Hôpital Arnaud de Villeneuve
🇫🇷Montpellier, France
Allergy & Asthma Medical Group & Research Center, Pc
🇺🇸Long Beach, California, United States
Pneumologisches Zentrum Wiesloch
🇩🇪Wiesloch, Germany
Creekside Medical Research
🇺🇸DeLand, Florida, United States
ADAC Research PA
🇺🇸Greenville, South Carolina, United States
Manassas Clinical Research Center
🇺🇸Manassas, Virginia, United States
Alberta Health Services
🇨🇦Calgary, Alberta, Canada
Centre d'investigation Clinique Mauricie
🇨🇦Trois-Rivières, Quebec, Canada
Barzilai Medical Center; Pulmonary Inst.
🇮🇱Ashkelon, Israel
Hospital de la Santa Creu; i Sant Pau
🇪🇸Barcelona, Spain
Grazyna Pulka Specjalistyczny Ośrodek ALL-MED
🇵🇱Krakow, Poland
Centrum Alergologii Teresa Hofman
🇵🇱Poznan, Poland
Alian s.r.o.
🇸🇰Bardejov, Slovakia
Plucna ambulancia
🇸🇰Spisska Nova Ves, Slovakia
C.C.C. Hospital Chest Diseases
ðŸ‡ðŸ‡ºSzeged, Hungary
Centrum Medycyny Oddechowej Robert M. Mróz
🇵🇱Bialystok, Poland
Specjalistyczne Centrum Medyczne NOWOMED
🇵🇱Kraków, Poland
Prof.Dr.Octavian Fodor Emergency Clinical Hospital
🇷🇴Cluj-Napoca, Romania
Tehelná Clinic, Inc; IMUNO-ALERGO, s. r.o.
🇸🇰Bratislava, Slovakia
SPZOZ Proszowice
🇵🇱Proszowice, Poland
Medica Pro Familia Sp. z o.o. S.K.A.
🇵🇱Warszawa, Poland
Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k.
🇵🇱Kraków, Poland
ALL-MED Specjalistyczna Opieka Medyczna
🇵🇱Wroclaw, Poland
Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Victor Babes Craiova
🇷🇴Craiova, Romania
Clinical Hospital Center ''Bezanijska Kosa''; Department of Pulmology
🇷🇸Belgrade, Serbia
Regional Phthisiology and Pulmonology Center
🇺🇦Ivano-Frankivsk, Ukraine
Yanovskyy Inst of Phth. & Pulm; Clinical-functional
🇺🇦Kyiv, Ukraine
City Clinical Hospital #27
🇺🇦Kharkiv, Ukraine
Danylo Halytskyy National Medical University; Lviv
🇺🇦Lviv, Ukraine
Medical and Sanitary Unit of OJSC "Kharkiv Tractor Plant n.a. Ordzhonikidze"; Department of Therapy
🇺🇦Kharkiv, Ukraine
Public Institution City Clinical Hospital # 6 of Dnipropetrovsk Regional Board
🇺🇦Dnepropetrovsk, Ukraine
Central Outpatient Hospital of Desnyansky District
🇺🇦Kyiv, Ukraine
Marycliff Allergy Specialists
🇺🇸Spokane, Washington, United States
Azienda Ospedaliero Universitaria di Parma
🇮🇹Parma, Emilia-Romagna, Italy
Allergy & Asthma Research Center of El Paso
🇺🇸El Paso, Texas, United States
Montefiore Medical Center
🇺🇸The Bronx, New York, United States