Does the Speed of Imagined Muscle Contractions Affect Muscle Function and Central Nervous System Excitability?
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Change in rate of torque development as measured by newton-meters per second
研究概览
简要总结
The goal of this randomized clinical trial is to learn if imagining fast or slow muscle contractions causes different responses for nervous system excitability and muscle function in young, healthy males and females in. The main questions are:
Does imagining fast muscle contractions cause greater nervous system excitability compared to imagining slow muscle contractions?
Does imagining fast muscle contractions increase muscle function compared to imagining slow muscle contractions?
A control condition (rest) will be compared with two intervention conditions: imagining fast and imagining slow conditions, to determine if the fast and slow increase outcomes more than control and if fast has the greatest response.
Participants will:
- Attend 4 laboratory visits
- Perform 50 imagined contractions fast or slow, but with no physical movement
- Physical muscle contractions and non-invasive brain stimulation would be completed before and after each condition.
详细描述
Participants will complete 4 laboratory visits in a randomized order, including a familiarization session, a control condition, and 2 conditions involving imaginary muscle contractions. During visits involving imaginary muscle contractions, participants will complete 2 sets of 25 repetitions of either fast (i.e., less than 1 second to peak torque increase torque as fast as possible) or slow (i.e., 3 seconds to peak torque) isometric elbow flexions. Before and after each condition, single-pulse transcranial magnetic stimulation will be delivered to the primary motor cortex to measure the amplitude of motor-evoked potentials and the duration of the resulting silent periods in the bicep brachii to quantify changes in corticospinal excitability and inhibition, respectively. Rapid maximal voluntary isometric contractions will be used to measure changes in rate of torque development, peak torque, and rate of muscle activation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Be between the ages of 18 - 30
- •Healthy (no medical conditions)
- •If female, must be taking the same monophasic oral contraceptive for the past 6 months
- •Have a body mass index between 18.5 - 30 kg/m2
- •Have not performed structured cardiovascular or resistance exercise in past 3 years
- •Be right-handed
- •Not currently taking stimulants, antipsychotic, anxiety, or depression medications
- •Have not suffered an upper extremity musculoskeletal injury within the past year
排除标准
- •If transcranial magnetic stimulation (TMS) is not deemed appropriate depending on your responses to the TMS-specific questionnaire
- •Being ambidextrous
- •Although rare, you will be excluded if discernable muscle activation responses are not possible via TMS
结局指标
主要结局
Change in rate of torque development as measured by newton-meters per second
时间窗: Baseline, minute 20
A measure of the capacity to increase muscle torque rapidly as determined by the slope of the torque-time curve
Change in nervous system excitability as measured by electromyographic waveform aplitude following motor cortex stimulation
时间窗: Baseline, minute 20
A measure of excitability for the corticospinal tract
次要结局
- Change in isometric bicep strength as measured by newton-meters of torque(Baseline, minute 20)
- Change in agonist muscle activation as measured by electromyography amplitude(Baseline, minute 20)
- Change in antagonist co-activation as measured by electromyography amplitude(Baseline, minute 20)
- Change in rate of agonist muscle activation as measured by electromyography amplitude(Baseline, minute 20)
- Change in nervous system inhibition as measured by electromyographic waveform aplitude following motor cortex stimulation(Baseline, minute 20)
研究者
Garrett Hester
Associate Professor of Exercise Science
Kennesaw State University