Comparative Study Between the Effect of Volume-Controlled Ventilation and Pressure-Controlled Ventilation Volume Guaranteed in Obese Patients in Laparoscopic Assisted Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 64
- 试验地点
- 2
- 主要终点
- Oxygenation index
研究概览
简要总结
The aim of this study is to compare the efficacy of the pressure controlled ventilation volume-guaranteed (PCV-VG) versus volume-controlled ventilation (VCV) modes as regards lung compliance and oxygenation index in obese patients undergoing laparoscopic assisted surgery especially in Trendelenburg position.
详细描述
Obesity, defined as a Body Mass Index (BMI) >30 kg.m-2", is characterized by increased airway resistance, labored breathing and decreased respiratory system compliance. An increased rate of obese patients undergoing laparoscopic assisted surgery (LAS) is a health care concern due to anesthesia and ventilation difficulties in the obese population. Therefore, understanding the physiology and pathophysiology of lung function is an important issue during long-lasting LAS.
Carbon dioxide pneumoperitoneum with steep Trendelenburg positioning leads to a cranial displacement of the diaphragm and an increased volume of atelectasis, with a consequent decrease of total lung volume, lung compliance, and functional residual capacity. Thus, alleviation of increased airway pressure, improvement in oxygenation and CO2 elimination are the main goals during anesthetic management in laparoscopic assisted surgery.
In pressure controlled ventilation volume-guaranteed (PCV-VG) mode, the ventilator regulates the Peak Inspiratory Pressure (PIP) to achieve the optimal TV. To achieve the target volume, ventilator parameters are regularly changed without adjusting airway pressures. Hence, PCV-VG has the advantages of both Volume-Controlled Ventilation (VCV) and pressure controlled ventilation (PCV) to preserve the target minute ventilation while maintaining a low incidence of barotraumas.
PCV-VG is a type-controlled ventilation mode with a dual character as it has the criteria of both PCV and VCV. This recent ventilation mode which is one of the pressure regulated volume controlled (PRVC) that include Auto Flow ventilation, offers the ability to reduce the inspiratory pressure and as a result the incidence of barotrauma
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 16 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 16 - 60 years old.
- •Sex: both males and females.
- •Undergoing elective Laparoscopic Surgery.
- •Obese patient with Body Mass Index between ≥30 Kg/m
- •American society of Anesthesiologist (ASA) class I/ II.
排除标准
- •Patient refusal.
- •American society of Anesthesiology (ASA) III or IV.
- •Intraoperative hemodynamic instability.
- •Patients with pulmonary hypertension.
- •Obese patients on home O2 therapy
- •Pneumoperitoneum with CO2 with intra-abdominal pressure exceeding 15mmHg.
- •Anti-Trendelenburg position.
- •Asthmatic Patients.
- •Patients with advanced liver disease.
- •Patients with advanced renal disease.
- •Patients with advanced malignancy.
- •Pregnant females.
结局指标
主要结局
Oxygenation index
时间窗: Till the end of surgery
Oxygenation index =mean airway pressure × fraction of inspired oxygen (FiO2) × 100÷ Partial pressure of oxygen (PaO2)
次要结局
- Arterial PCo2(Till the end of surgery)
- Heart rate(Till the end of surgery)
- Lung compliance(Till the end of surgery)
- Oxygen saturation SpO2(Till the end of surgery)
- Mean arterial blood pressure(Till the end of surgery)
研究者
Ahmed Maamoun Maamoun Soliman
Assistant lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine
Ain Shams University