Effects of MCDG Oil on Postprandial Lipid Metabolism

Not Applicable

Completed

• Conditions: Hyperlipidemias; Triglycerides High
• Interventions: Dietary Supplement: MCDG oil; Dietary Supplement: LCT oil

• Registration Number: NCT03415568
• Lead Sponsor: Yonsei University

Brief Summary

It is well known that medium chain triglycerides (MCTs) and diacylglycerols (DGs) have effects on lowering circulating triglycerides (TGs). In this study, the mixture of MCTs and DGs (MCDGs) examined whether it has beneficial effects on postprandial lipids metabolism compared to long-chain triglycerides (TGs).

Detailed Description

A randomized, double-blinded, controlled, cross-over trial was conducted to verify the effects of MCDGs. Twenty-eight healthy male and female subjects aged 21-29 years with normal body weight \[18.5 kg/m\^2 ≤ body mass index (BMI) \< 25 kg/m\^2\] were recruited. The subjects visited the research site twice over with a seven-day interval after an overnight fast at least 12 hr. On the first visit, the participants were randomly assigned to consume a test or placebo product \[test product: muffins containing MCDG oil (MCDG muffin); placebo product: muffins containing LCT oil (LCT muffin)\] and ingested the assigned product. On the second visit, the participants consumed the other product that they did not eat on the first visit. On both visit day, the 6-hr meal tolerance test was conducted and started at 8:00 in the morning; venous blood samples were collected before (0 hr) and after ingestion (2, 3, 4, and 6 hr) of the products.

Study Timeline

• Study Start: 2017-06-30
• Primary Completion: 2017-07-28
• Study Completion: 2017-07-28
• Status Verified: 2018-01
• Study First Submitted: 2018-01-15
• Study First Submitted QC: 2018-01-29
• Last Update Submitted: 2018-01-29
• Study First Posted: 2018-01-30
• Last Update Posted: 2018-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Healthy subjects with normal body weight (18.5 kg/m^2 ≤ body mass index (BMI) < 25 kg/m^2)

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Exclusion Criteria

• history/presence of hypertension, diabetes mellitus, hyperlipidemia, cardiovascular disease, liver disease, gastrointestinal disease, thyroid disease, or any other acute or chronic diseases requiring treatment
• Use of any medication affecting body weight or energy expenditure for 1 month before screening

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
MCDG consumption	MCDG oil	Muffin that contains 15g of the mixture of medium-chain triglyceride and diacylglycerol (MCDG) oils were provided to conduct 6-h meal tolerance test.
LCT consumption	LCT oil	Muffin that contains 15g of long-chain triglyceride (LCT) oils were provided to conduct 6-h meal tolerance test.

Primary Outcome Measures

Name	Time	Method
Triglyceride levels	6 hours	Triglyceride level differences during the 6-hr meal tolerance test between LCT and MCDG muffins intake

Secondary Outcome Measures

Name	Time	Method
The areas under the curve (AUC) of triglycerides	1 day of second visit (after finishing cross-over trial)	Triglyceride AUC differences between LCT and MCDG muffins intake
Triglyceride maximum concentration time	1 day of second visit (after finishing cross-over trial)	The time when triglyceride peaks maximum concentration during the 6-h meal tolerance test

Trial Locations

Locations (1)

Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University.; 🇰🇷 Seoul, Korea, Republic of