Analgesia After Video-Assisted Thoracic Surgery

Phase 2

• Conditions: Post Operative Pain
• Interventions: Drug: Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine; Drug: Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine; Drug: Local wound infiltration with isobaric bupivacaine

• Registration Number: NCT05094323
• Lead Sponsor: Assiut University

Brief Summary

Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).

Detailed Description

Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).

Adequate postoperative pain relief is imperative to hasten functional recovery, accelerate discharge from the hospital, and reduce chronic postsurgical pain.

Study Timeline

• Study First Submitted: 2021-10-14
• Study First Submitted QC: 2021-10-14
• Study First Posted: 2021-10-26
• Status Verified: 2022-02
• Study Start: 2022-02-18
• Last Update Submitted: 2022-02-18
• Last Update Posted: 2022-03-04
• Primary Completion: 2023-01
• Study Completion: 2023-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• Patients scheduled for uniportal VATS under general anesthesia, ASA status I-III, aged from 18 to 70 years old of both sex.

Exclusion Criteria

• Contraindications to regional block
• Pregnancy
• Body mass index (BMI) > 30 Kg/m2
• Psychiatric diseases
• Severe renal, liver, or cardiac dysfunction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group I	Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine	Patients will receive ultrasound-guided deep serratus anterior plane block.
Group III	Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine	Patients will receive ultrasound-guided thoracic paravertebral block.
Group II	Local wound infiltration with isobaric bupivacaine	Patients will receive local wound infiltration (LWI).

Primary Outcome Measures

Name	Time	Method
Time to first analgesic requirement	24 hours after surgery	Assessed in minutes

Secondary Outcome Measures

Name	Time	Method
Postoperative pain intensity	24 hours after surgery	Assessed by the numerical rating pain scale, an 11-point scale graded from 0 to 10 (0 = no pain, 10 = the worst imaginable pain)

Trial Locations

Locations (1)

Seham M. Moeen; 🇪🇬 Assiut, Egypt