Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 69
- 试验地点
- 8
- 主要终点
- voluntary maximum force reduction
研究概览
简要总结
Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This symptom seems particularly pronounced in Covid-19 patients and may affect their quality of life by decreasing their capacity to perform simple tasks of daily life.
The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in the feeling of fatigue of Covid-19 patients. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology and its recovery will allow to optimize rehabilitation treatments to shorten the persistence of chronic fatigue and in fine improve life quality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Taking neuroactive substances that can alter corticospinal excitability
- •Patients with co-morbidities leading to significant fatigue: e.g. cancerous pathologies, sleep apnea
- •Patients with neurodegenerative or neuromuscular disease
- •Contraindication to the application of a magnetic field
- •Contraindication to the practice of Magnetic Resonance Imaging
- •Participant is pregnant
- •Patients with psychiatric disorders
- •Paraplegic and hemiplegic patients
- •Addictive disorders
研究组 & 干预措施
"Non-fatigued" patients who have been in intensive care units
干预措施: food diary (Other)
"Fatigued" patients who have been in intensive care units
干预措施: Questionnaires (Other)
"Non-fatigued" patients who have been in intensive care units
干预措施: Questionnaires (Other)
"Non-fatigued" patients who have been in intensive care units
干预措施: blood test (Biological)
"Non-fatigued" patients who have been in intensive care units
干预措施: Maximal effort test (Other)
"Non-fatigued" patients who have been in intensive care units
干预措施: actigraphy (Device)
"Non-fatigued" patients who have been in intensive care units
干预措施: Neuromuscular evaluation (Device)
"Non-fatigued" patients who have been in intensive care units
干预措施: stool analysis (Other)
"Fatigued" patients who have been in intensive care units
干预措施: blood test (Biological)
"Fatigued" patients who have been in intensive care units
干预措施: Maximal effort test (Other)
"Fatigued" patients who have been in intensive care units
干预措施: actigraphy (Device)
"Fatigued" patients who have been in intensive care units
干预措施: Neuromuscular evaluation (Device)
"Fatigued" patients who have been in intensive care units
干预措施: stool analysis (Other)
"Fatigued" patients who have been in intensive care units
干预措施: food diary (Other)
patients who have not been in intensive care units
干预措施: Questionnaires (Other)
patients who have not been in intensive care units
干预措施: blood test (Biological)
patients who have not been in intensive care units
干预措施: Maximal effort test (Other)
patients who have not been in intensive care units
干预措施: actigraphy (Device)
patients who have not been in intensive care units
干预措施: Neuromuscular evaluation (Device)
patients who have not been in intensive care units
干预措施: stool analysis (Other)
patients who have not been in intensive care units
干预措施: food diary (Other)
结局指标
主要结局
voluntary maximum force reduction
时间窗: 6 weeks post-discharge
次要结局
- Neuromuscular function : cortical activity(6 weeks post-discharge)
- Neuromuscular function : Peripheral function(6 weeks post-discharge)
- Maximal oxygen uptake (VO2max)(6 weeks post-discharge)
- metabolic fatigue(6 weeks post-discharge)
- quality of sleep(6 weeks post-discharge)
- muscle volume(6 weeks post-discharge)
- microbiote intestinal(baseline and 6 months)