Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- voluntary maximum force reduction
研究概览
简要总结
Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life.
The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in this feeling of chronic fatigue. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology will allow to optimize rehabilitation treatments to decrease the apparition/persistence of chronic fatigue and in fine improve life quality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Have been ventilated for at least 72 hours in the intensive care unit
- •IGS2 score (severity in resuscitation) > 15
- •FACIT-F (Functional Assessment of Chronic Illness Therapy-Fatigue) score ≥ 36 or a score ≤ 32
- •intensive care unit discharge in ≥ 6 months and ≤ 5 years preceding the study
- •Approval received from a physician
- •Command of the French language
排除标准
- •Taking neuroactive substances that can alter corticospinal excitability
- •Contraindication to the application of a magnetic field
- •Contraindication to the practice of Magnetic Resonance Imaging
- •Participant is pregnant
- •Patients with psychiatric disorders
- •Paraplegic and hemiplegic patients
- •Addictive disorders
结局指标
主要结局
voluntary maximum force reduction
时间窗: at 2 weeks
次要结局
- muscle dysfunction (optional)(at 3 weeks)
- Quadriceps muscle volume (optional)(at 3 weeks)
- quality of sleep(at baseline)
- Neuromuscular function : cortical activity(at 2 weeks)
- Maximal oxygen uptake (VO2max)(at 2 weeks)
- Neuromuscular function : Peripheral function(at visit 2)